A Losart 50 Tablet
Losartan Potassium
50mg
Acme Laboratories Ltd
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Available as:
Indications
A Losart 50 Tablet is used for:
Diabetic nephropathy, Hypertension, Stroke risk reduction of hypertensive or LVH patients, Heart Failure, Hypertensive Patients with Left Ventricular Hypertrophy
Adult Dose
Oral
Hypertension
Adult: 50 mg once daily, may increase to 100 mg/day as single dose or in 2 divided doses if needed. Patients w/ intravascular volume depletion: Initially, 25 mg once daily.
Diabetic nephropathy in Type 2 diabetes mellitus
Adult: Initially, 50 mg once daily, may increase to 100 mg once daily depending on BP response.
Heart failure, Hypertension and Left Ventricular Hypertrophy, Stroke risk reduction of hypertensive or LVH patients:
Adult: Initially, 50 mg once daily. Hydrochlorothiazide 12.5 mg daily should be added and/or the dose of Losartan should be increased to 100 mg once daily followed by an increase in hydrochlorothiazide to 25 mg once daily based on blood pressure response
Child Dose
Hypertension
<6 years: Safety and efficacy not established
Child: >6 yr 20-50 kg: Initially, 0.7 mg/kg. Max: 50 mg/day;
>50 kg: Initially, 1.4 mg/kg. Max: 100 mg/day.
Renal Dose
Renal impairment: CrCl <20 ml/min: Initially 25 mg once daily.
Administration
May be taken with or without food.
Contra Indications
Losartan potassium is contraindicated in patients who are hypersensitive to the active ingredient or any component of the drug. Concomitant use w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min). Severe hepatic impairment. Pregnancy.
Precautions
Volume-depleted patients including patients on high-dose diuretics. Patients w/ bilateral renal artery stenosis , aortic or mitral stenosis. Renal and mild to moderate hepatic impairment. Lactation. Monitoring Parameters Monitor BP, electrolytes and renal function.
Lactation: Unknown if excreted in milk; not recommended
Pregnancy-Lactation
Pregnancy Categories C (first trimester) and D (second and third trimesters).
Interactions
May decrease plasma levels / fluconazole and rifampicin. May increase serum lithium levels and toxicity. May antagonise hypotensive effect and increase risk of renal impairment w/ NSAIDs. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes.
Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).
Adverse Effects
Side effects of Losartan Potassium :
>10%
Fatigue (14%),Hypoglycemia (14%),Anemia (14%),Urinary tract infection (UTI) (13%),Chest pain (12%),Weakness (14%),Diarrhea (2-15%),Cough; incidence higher in previous cough related to angiotensin-converting enzyme (ACE) inhibitor therapy (3-11%)
1-10%
Upper respiratory tract infection (8%),Hypotension (7%),Dizziness (4%),Cellulitis (7%),Gastritis (5%),Nausea (2%)
Frequency Not Defined
Angioedema,Edema/swelling,Hypotension in hypovolemic or diuretic-using patients,Asthenia,Headache,Malaise,Nausea,Abdominal pain,Hyperkalemia,Back pain,Worsening renal failure
Mechanism of Action
Losartan is an angiotensin II receptor antagonist. It selectively and competitively blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors.
Note
A Losart 50 50mg Tablet manufactured by Acme Laboratories Ltd. Its generic name is Losartan Potassium. A Losart 50 is availble in Nepal.
Farmaco Nepal drug index information on A Losart 50 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.