Accutaz PS 250/31.25 Injection
Ceftriaxone + Tazobactam
Macleods Pharmaceuticals Pvt. Ltd.
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Available as:
Indications
Accutaz PS 250/31.25 Injection is used for:
Bacterial meningitis, Bone and joint infections, Community-acquired pneumonia, Intra-abdominal infections, Lower respiratory tract infections, Pelvic inflammatory disease, Uncomplicated gonorrhoea, Skin and skin structure infections, Bacterial septicaemia, Urinary tract infections
Adult Dose
Intravenous
Bacterial meningitis, Bone and joint infections, Community-acquired pneumonia, Intra-abdominal infections, Lower respiratory tract infections, Pelvic inflammatory disease, Uncomplicated gonorrhoea, Skin and skin structure infections, Bacterial septicaemia, Urinary tract infections
Adult: Expressed in terms of ceftriazone/tazobactam: 1000/125 mg once daily or in equally divided doses twice a day. Total daily dose should not exceed 4 g of ceftriaxone. Continue treatment for at least 2 days after the signs and symptoms have resolved. Usual duration: 7-14 days; longer treatment may be needed in more serious infections. For Streptococci pyogenes infections, treatment should continue for at least 10 days.
Child Dose
Intravenous
Bacterial meningitis, Bone and joint infections, Community-acquired pneumonia, Intra-abdominal infections, Lower respiratory tract infections, Pelvic inflammatory disease, Uncomplicated gonorrhoea, Skin and skin structure infections, Bacterial septicaemia, Urinary tract infections
Child: Expressed in terms of ceftriaxone: Serious infections: 50-75 mg/kg/day, given in divided doses every 12 hr. Total daily dose should not exceed 2 g of ceftriaxone. Continue treatment for at least 2 days after the signs and symptoms have resolved. Usual duration: 7-14 days; longer treatment may be needed in more serious infections. For Streptococci pyogenes infections, treatment should continue for at least 10 days.
Renal Dose
Administration
Contra Indications
Hypersensitivity to cephalosporins and beta-lactamase inhibitors.
Precautions
History of penicillin allergy; lactation. Consider possibility of pseudomembranous colitis in patients who present with diarrhoea subsequent to the admin of antibacterial agents. Monitor prothrombin time in patients with impaired vit K synthesis or low vit K stores during treatment. Prolonged treatment may result in overgrowth of nonsusceptible organisms. Caution in patients with a history of GI disease, especially colitis. Discontinue treatment in patients who develop signs/symptoms suggestive of gallbladder disease. Not to be used in hyperbilirubinemic neonates, especially prematures.
Pregnancy-Lactation
Interactions
Probenecid; aminoglycosides; vecuronium, methotrexate; oral anticoagulants; heparin.
Potentially Fatal: Disulfiram-like reaction with alcohol. Nephrotoxicity with aminoglycosides and furosemide.
Adverse Effects
Side effects of Ceftriaxone + Tazobactam :
Superinfection; anaphylaxis; diarrhoea; local reactions; blood dyscrasias; rash, fever, pruritus; elevated transaminases and alkaline phosphatase. GI effects; pseudomembranous colitis; hematologic effects; hypersensitivity reactions; CNS disturbances; hypertension; chest pain; edema; moniliasis; rhinitis; dyspnea; hypotension; ileus; syncope; local Inj site reactions; rigors.
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Mechanism of Action
Ceftriaxone interferes with the biosynthesis of the peptidoglycan component of the bacterial cell way by binding to and inactivating penicllin-binding proteins (PBPs). Tazobactam is a penicillanic acid sulfone derivative with β-lactamase inhibitory properties. It enhances the activity of β-lactam antibacterials against beta-lactamase-producing bacteria.
Note
Accutaz PS 250/31.25 Injection manufactured by Macleods Pharmaceuticals Pvt. Ltd.. Its generic name is Ceftriaxone + Tazobactam. Accutaz PS 250/31.25 is availble in Nepal.
Farmaco Nepal drug index information on Accutaz PS 250/31.25 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.