Acitac S Tablet
Ranitidine
150mg
G.D. Laboratories Pvt. Ltd.
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| Retail Price | 1.30 NPR |
Indications
Acitac S Tablet is used for:
Dyspepsia, H. pylori infection, Benign gastric and duodenal ulceration, GERD, Acid aspiration during general anesth, Prophylaxis during NSAID treatment, Stress ulceration of upper GI, Zollinger-Ellison syndrome
Adult Dose
Oral
Benign gastric and duodenal ulceration
Adult: Initially, 300 mg daily at bedtime or 150 mg bid for 4-8 wk; 300 mg bid for 4 wk may be used in duodenal ulcer to improved healing. Maintenance: 150 mg daily at bedtime. Max: 300 mg bid.
Hypersecretory conditions
Adult: Initially, 150 mg bid or tid and increased if needed. Max: 6 g daily.
Gastro-oesophageal reflux disease
Adult: 150 mg bid or 300 mg at bedtime for up to 8 wk, may increase to 150 mg 4 times daily for 12 wk in severe cases.
Dyspepsia
Adult: Chronic episodic: 150 mg bid for up to 6 wk. Short-term symptomatic relief: 75 mg repeated if necessary up to 4 doses daily. Max duration: 2 wk of continuous use at one time.
Erosive oesophagitis
Adult: 150 mg 4 times daily. Maintenance: 150 mg bid.
NSAID-associated ulceration
Adult: 150 mg bid or 300 mg at bedtime for 8-12 wk. For prevention of NSAID-associated ulceration: 150 mg bid.
Hepatic impairment: Dosage adjustment not necessary
Child Dose
Oral
Benign gastric and duodenal ulceration
Child: 1 mth to 16 yr 4-8 mg/kg daily in 2 divided doses. Max: 300 mg/day. Treatment duration: 4-8 wk. Maintenance: 2-4 mg/kg once daily. Max: 150 mg/day.
Gastro-oesophageal reflux disease
Child: 1 mth to 16 yr 5-10 mg/kg daily in 2 divided doses. Max: 300 mg/day.
Erosive oesophagitis
Child: 1 mth to 16 yr 5-10 mg/kg daily in 2 divided doses. Max: 600 mg/day.
Renal Dose
Oral:
CrCl Dosage
<50 150 mg daily at bedtime, adjust dose cautiously if necessary.Parenteral:
Individual doses may be reduced to 25 mg.
Administration
May be taken with or without food.
IV Administration
Direct injection: 50 mg diluted to ?20 mL with compatible IV infusion fluid and given over ?5 minutes (4 mL/min)
Intermittent infusion: 50 mg added to ?100 mL of compatible IV solution and infused over 15-20 minutes
Continuous infusion: 150 mg diluted in 250 mL of IV fluid and infused at 6.25 mg/hr for 24 hours
Contra Indications
Porphyria.
Precautions
Possibility of malignancy should be excluded prior to therapy as the drug may mask symptoms and delay diagnosis of gastric malignancy. Patients w/ difficulty in swallowing. Renal and hepatic impairment. Pregnancy and lactation.
Lactation: Drug crosses into breast milk; discontinue drug, use caution
Pregnancy-Lactation
Interactions
Delayed absorption and increased peak serum concentration w/ propantheline bromide. Ranitidine minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability w/ antacids.
Adverse Effects
Side effects of Ranitidine :
1-10%
Headache (3%)
<1%
Abdominal pain,Agitation,Alopecia,Confusion,Constipation,Diarrhea,Dizziness,Hypersensitivity reaction,Nausea,Vomiting
Frequency Not Defined
Anemia,Necrotizing enterocolitis in fetus or newborn,Pancreatitis (rare),Thrombocytopenia (rare),Pancytopenia (rare),Agranulocytosis (rare),Acquired immune hemolytic anemia (rare),Arthralgia (rare),Myalgia (rare)
Potentially Fatal: Anaphylaxis, hypersensitivity reactions.
Mechanism of Action
Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Note
Acitac S 150mg Tablet manufactured by G.D. Laboratories Pvt. Ltd.. Its generic name is Ranitidine. Acitac S is availble in Nepal.
Farmaco Nepal drug index information on Acitac S Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.