Acivir Cream
Acyclovir 5% Topical
5% w/w
Cipla Ltd.
| Pack size | 5gm |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 91.25 NPR |
Indications
Acivir Cream is used for:
Herpes virus infections of skin
Adult Dose
As 5% oint/cream: Apply 5-6 times/day for 5-10 days.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration.
Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application.
Pregnancy-Lactation
Interactions
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Adverse Effects
Side effects of Acyclovir 5% Topical :
>10%
Burning/stinging (30%)
1-10%
Pruritus (4%)
<1%
Dry lips (<1%),Rash (0.3%)
Frequency Not Defined
Angioedema,Vulvitis
Mechanism of Action
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Note
Acivir 5% w/w Cream manufactured by Cipla Ltd.. Its generic name is Acyclovir 5% Topical. Acivir is availble in Nepal.
Farmaco Nepal drug index information on Acivir Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.