Indications
Aerrane Solution is used for:
General anaesthesia
Adult Dose
Anesthesia Induction & Maintenance
Use calibrated vaporizer
Induction: 1.5-3% can produce surgical anesthesia in 7-10 minutes
Maintenance: 1-2.5% with nitrous oxide
Additional 0.5-1% may be needed if given with oxygen alone
Child Dose
Safety & efficacy not established
Renal Dose
Administration
Contra Indications
Known or suspected susceptibility to malignant hyperthermia. Porphyria.
Precautions
Perioperative hyperkalaemia; raised intracranial pressure. May impair ability to drive or operate machinery. Pregnancy and lactation. Do not allow carbon dioxide absorbents in anaesthetic apparatus to dry out when delivering isoflurane to minimise the risk of developing elevated carboxyhaemoglobin levels.
Lactation: use caution
Pregnancy-Lactation
Interactions
Enhances effects of neuromuscular blockers. May sensitise the myocardium to adrenaline and other sympathomimetics. Enhances hypotensive effects of ACE inhibitors, TCAs, MAOIs, antihypertensives, antipsychotics or beta-blockers. May have synergistic effects with CNS depressants.
Adverse Effects
Side effects of Isoflurane :
1-10%
Nausea,Vomiting,Shivering
<1%
Dose-dependent hypotension,Arrhythmias,Malignant hyperthermia (rare),Elevations in white blood count,May decrease creatinine and increase BUN,Ileus, severe (fatal),Hepatic dysfunction (postoperative period) (rare),Respiratory depression may occur (rare)
Mechanism of Action
Isoflurane, a volatile halogenated anaesthetic, causes a reversible loss of consciousness and pain sensations, suppression of voluntary motor activity, modification of autonomic reflexes, and depression of the respiratory and the CV system.
Note
Aerrane Solution manufactured by Baxter Healthcare. Its generic name is Isoflurane. Aerrane is availble in Nepal.
Farmaco Nepal drug index information on Aerrane Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.