Alphadol Capsule

Alfacalcidol
0.25mcg
Panacea Biotec Ltd.
Pack size 10's
Dispensing mode
Source
Agent
Retail Price 15.86 NPR

Indications

Alphadol Capsule is used for: Hypoparathyroidism, Hypocalcaemia, Renal osteodystrophy, Hypophosphataemia, Rickets or osteomalacia

Adult Dose

Adult: PO Hypocalcaemia; Hypoparathyroidism; Hypophosphataemia; Renal osteodystrophy; Rickets or osteomalacia Initial: 1 mcg/day. Maintenance: 0.25-1 mcg/day. Elderly: 0.5 mcg daily.

Child Dose

Child: PO: Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.

Renal Dose

Administration

Administration Should be taken with food.

Contra Indications

Hypercalcaemia, metastatic calcification, hyperphosphataemia (except when occurring with hypoparathyroidism), hypermagnesaemia.

Precautions

Pregnancy, lactation, renal impairment, infants, elderly. Monitor serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. Avoid in patients with hypersensitivity to inj. containing propylene glycol.

Pregnancy-Lactation

Interactions

Thiazides may increase the risk of hypercalcaemia. Some antiepileptics e.g. carbamazepine, phenobarbital, phenytoin and primidone may increase vitamin D requirements. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D.

Adverse Effects

Side effects of Alfacalcidol : Anorexia, nausea, vomiting, diarrhoea, lassitude, polyuria, sweating, headache, thirst, vertigo, pruritus, rash, urticaria. Hypercalcaemia, hypercalciuria and ectopic calcification. In case of renal impairment, hyperphosphataemia. In hypercalcaemic dialysis patients, possibility of calcium influx from the dialysate should be considered.

Mechanism of Action

Alfacalcidol is a precursor of the active calcitriol. It does not require renal hydroxylation but requires 25-hydroxylation in the liver for conversion to calcitriol.

Note

Alphadol 0.25mcg Capsule manufactured by Panacea Biotec Ltd.. Its generic name is Alfacalcidol. Alphadol is availble in Nepal. Farmaco Nepal drug index information on Alphadol Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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