Amantrel Capsule
Amantadine Hydrochloride
100mg
Cipla Ltd.
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| Retail Price | 16.21 NPR |
Indications
Amantrel Capsule is used for:
Parkinson's disease, Influenza, herpes zoster, drug-induced extrapyramidal reactions
Adult Dose
Adult: PO Influenza A 100 mg/day for 5 days. Prophylaxis of influenza A 100 mg/day for up to 6 wk. W/ influenza vaccination: up to 3 wk after vaccination.
Elderly: >65 yr: Daily dose of <100 mg or 100 mg given at intervals >1 day.
Herpes zoster 100 mg twice daily for 14 days, may continue for another 14 days if pain persists.
Parkinson's disease100 mg/day, up to 100 mg twice daily 1 wk or more. Max: 400 mg/day.
Child Dose
Oral
Influenza A treatment
Child: 1-9 years or <40 kg (any age): 5 mg/kg/day PO in single dose or divided q12 hr; not to exceed 150 mg/day
>10 years and <40 kg: 5 mg/kg/day PO divided q12hr
>10 years and >40 kg: 100 mg PO q12hr
NOTE: Because of resistance, amantadine is no longer recommended for prophylaxis or treatment of influenza A
Renal Dose
Renal impairment:
CrCl (ml/min)
>35 100 mg daily.
15-35 100 mg every 2-3 days.
<15 Not recommended.
Administration
Should be taken with food.
Contra Indications
Hypersensitivity. Pregnancy and lactation. Epilepsy or other seizure disorders, severe renal impairment and gastric ulceration.
Precautions
Patients with CV or liver disease, impaired renal function, recurrent eczema. Elderly. Withdrawal of the drug should be gradual.
Lactation: Drug enters breast milk; not recommended
Pregnancy-Lactation
Interactions
Enhances the adverse effects of antimuscarinics and levodopa. CNS stimulants, drugs that raise urinary pH.
The concurrent use of Amantadine hydrochloride with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated.
Adverse Effects
Side effects of Amantadine Hydrochloride :
1-10%
Agitation,Anorexia,Anxiety,Ataxia,Confusion,Constipation,Depression,Diarrhea,Dizziness,Dream abnormality,Dry nose,Fatigue,Hallucinations,Headache,Insomnia,Irritability,Livedo reticularis,Nausea,Nervousness,Orthostatic hypotension,Peripheral edema,Somnolence,Xerostomia
<1%
Amnesia,CHF,Decreased libido,Dyspnea,Eczematoid dermatitis,Euphoria,Hyperkinesis,Hypertension,Instances of convulsions,Leukopenia,Neutropenia,Oculogyric episodes,Psychosis,Rash,Slurred speech,Urinary retention,Visual disturbances,Vomiting,Weakness
Potentially Fatal: Congestive heart failure, convulsions.
Mechanism of Action
Amantadine is a weak dopamine agonist possessing antimuscarinic properties. It alters dopamine release and re-uptake. It also noncompetitively antagonises N-methyl-D-aspartate. As an antiviral drug, it inhibits replication of influenza type A virus.
Note
Amantrel 100mg Capsule manufactured by Cipla Ltd.. Its generic name is Amantadine Hydrochloride. Amantrel is availble in Nepal.
Farmaco Nepal drug index information on Amantrel Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.