Aminophylline Injection

Aminophylline
25mg
Hindusthan Pharmaceuticals Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 19.80 NPR

Indications

Aminophylline Injection is used for: Asthma, Acute bronchospasm, Chronic bronchitis, Emphysema, COPD

Adult Dose

Oral Chronic bronchospasm Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary. Intravenous Acute severe bronchospasm Adult: Loading dose: 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow inj or infusion over 20-30 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min. Elderly: Dose reduction may be ncessary. Hepatic impairment: Dose reduction may be ncessary.

Child Dose

Oral Chronic bronchospasm Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk. Intravenous Acute severe bronchospasm Child: Loading dose: same as adult dose. Maintenance dose: 6 mth-9 yr: 1 mg/kg/hr and 10-16 yr: 0.8 mg/kg/hr.

Renal Dose

Administration

Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.

Contra Indications

Hypersensitivity.

Precautions

Neonates, elderly, lactation, pregnancy, cardiac/hepatic diseases, peptic ulceration, hyperthyroidism, hypertension, epilepsy, heart failure, chronic alcoholism, acute febrile illness.

Pregnancy-Lactation

Interactions

Other xanthines. Clearance reduced by allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon-alpha, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, cigarette smoking. Corticosteroids, diuretics, beta2-agonists. Potentially Fatal: Increased risk of cardiac arrhythmias with sympathomimetics and halothane. Tachycardia with pancuronium. beta-blockers inhibit metabolism. Increased risk of convulsion with quinolones, ketamine.

Adverse Effects

Side effects of Aminophylline : Nausea, vomiting, abdominal pain, diarrhoea, headache, insomnia, dizziness, anxiety, restlessness; tremor, palpitations. Potentially Fatal: Convulsions, cardiac arrhythmias, hypotension and sudden death after too rapid IV injection.

Mechanism of Action

Aminophylline is a combination of theophylline and ethylenediamine. Ethylenediamine is inactive; it increases the solubility of theophylline in water. Theophylline relaxes bronchial smooth muscle. Suggested mechanisms are an increase in intracellular cAMP through inhibition of phosphodiesterase; adenosine receptor antagonism, prostaglandin antagonism and effects on intracellular calcium.

Note

Aminophylline 25mg Injection manufactured by Hindusthan Pharmaceuticals Ltd.. Its generic name is Aminophylline. Aminophylline is availble in Nepal. Farmaco Nepal drug index information on Aminophylline Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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