Amwel 10 Tablet

Amitriptyline Hydrochloride
10mg
Alive Pharmaceutical. Pvt. Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 2.40 NPR

Available as:

Indications

Amwel 10 Tablet is used for: Migraine headache, Depression, Neuropathic pain, Post-herpetic neuralgia, Nocturnal enuresis

Adult Dose

Adult: PO Depression Initial:50-75 mg/day; up to 150 mg/day if needed. Max: 300 mg/day in severe cases. Neuropathic pain Initial: 10-25 mg/day at night, up to 75 mg/day if needed. Migraine prophylaxis Initial: 10 mg/day at night. Maintenance: 50-75 mg/day at night. Elderly: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses.

Child Dose

PO Depression Child: Adolescent: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses. Nocturnal enuresis Child: 6-10 yr 10-20 mg/day; 11-16 yr 25-50 mg/day. All doses to be given at bedtime. Max duration: 3 mth.

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity, use of MAO inhibitors within the last 14 days; acute recovery phase post-MI. Concurrent usage with cisapride.

Precautions

Bipolar illness, pregnancy, lactation elderly, CVS disease, renal or liver impairment, epilepsy, thyroid dysfunction, DM. Avoid abrupt withdrawal; urinary retention, prostatic hyperplasia; chronic constipation; angle-closure glaucoma; phaeochromocytoma. Monitor for signs of clinical worsening, suicidality or behavioural changes. May increase risks associated with electro-convulsive therapy. May affect ability to drive or operate machinery. Lactation: Distributed in breast milk; do not nurse (AAP states effect on nursing infants is unknown but may be of concern)

Pregnancy-Lactation

Interactions

Increased risk of serotonin syndrome w/ SSRIs, TCAs, triptans, fentanyl, lithium, tramadol. May reduce plasma levels w/ barbiturates, rifampicin and other anticonvulsants. May increase plasma levels w/ methylphenidate, cimetidine, antipsychotics, Ca channel blockers. May precipitate cardiac arrhythmias w/ thyroid hormones. May reduce antihypertensive effects of debrisoquine, guanethidine and clonidine. May increase pressor effect of epinephrine and norepinephrine. May increase the risk of ventricular arrhythmias w/ antiarrhythmics (e.g. amiodarone or quinidine), antihistamines astemizole, terfenadine, some antipsychotics (pimozide, sertindole, and thioridazine), sotalol, cisapride and halofantrine. Potentially Fatal: Increased risk of serotonin syndrome w/ MAOIs, linezolid and methylene blue.

Adverse Effects

Side effects of Amitriptyline Hydrochloride : Postural hypotension, tachycardia, conduction disturbances. Dry mouth, wt gain, sour or metallic taste, stomatitis, constipation; blurring of vision, urinary retention, fatigue, dizziness, weakness, tremors, headache, confusion and delirium in elderly, sexual disturbances; peripheral neuropathy; urticaria, angioedema, sweating. Potentially Fatal: Cardiac arrhythmias.

Mechanism of Action

Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.

Note

Amwel 10 10mg Tablet manufactured by Alive Pharmaceutical. Pvt. Ltd.. Its generic name is Amitriptyline Hydrochloride. Amwel 10 is availble in Nepal. Farmaco Nepal drug index information on Amwel 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Amitriptyline Hydrochloride :