Ator EZ Tablet
Atorvastatin + Ezetimibe
10mg+10mg
Nepal Pharmaceuticals Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 18.00 NPR |
Indications
Ator EZ Tablet is used for:
Hypercholesterolaemia, Primary Hyperlipidemia
Adult Dose
Oral
Hypercholesterolaemia, Primary Hyperlipidemia
Adult: Per tablet contains atorvastatin 10 mg and ezetimibe 10 mg: Usual starting: 1 tablet once daily.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity; active liver disease or unexplained persistent elevated liver function tests. Pregnancy and lactation.
Precautions
Hepatic impairment; patients consuming substantial quantities of alcohol with a history of liver disease. Not recommended for use in children <10 yr.
Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breast feed. Contraindicated in breastfeeding women.
Pregnancy-Lactation
Interactions
Atorvastatin: Increases digoxin levels; increases anticoagulant effect of warfarin. Avoid the combination of HMG-CoA reductase inhibitors and fibrates. Ezetimibe: Cholestyramine decreases AUC of ezetimibe by approx 55%; ciclosporin may increase ezetimibe levels.
Potentially Fatal: Antacids decrease atorvastatin levels; colestipol decreases atorvastatin plasma levels; propranolol decreases antihyperlipidaemic activity of atorvastatin.
Adverse Effects
Side effects of Atorvastatin + Ezetimibe :
1-10%
Increased ALT (5%),Increased AST (4%),Musculoskeletal pain (4%),Abdominal pain (3%),Nausea (3%),Arthralgias (3%),Muscle weakness (2%),Dizziness (2%),Hyperkalemia (2%),Hot flushes (2%),Coughing (2%),Bronchitis (2%),Sinusitis (2%)
Mechanism of Action
Atorvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyses the conversion of HMG-CoA to mevalonate which is an early rate-limiting step in cholesterol biosynthesis. Ezetimibe inhibits the absorption of cholesterol from the intestine, thus decreasing the delivery of intestinal cholesterol to the liver.
Note
Ator EZ 10mg+10mg Tablet manufactured by Nepal Pharmaceuticals Pvt. Ltd.. Its generic name is Atorvastatin + Ezetimibe. Ator EZ is availble in Nepal.
Farmaco Nepal drug index information on Ator EZ Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.