Attentrol 18 Capsule
Atomoxetine
18mg
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Attentrol 18 Capsule is used for:
Attention deficit hyperactivity disorder (ADHD)
Adult Dose
Oral
Attention deficit hyperactivity disorder
Adult: Initially, 40 mg/day may increase gradually after at least 7 days to 80 mg/day, up to 100 mg/day may be used after 2-4 wk.
Hepatic impairment: Moderate: Reduce dose by 50%. Severe: Reduce dose by 75%.
Child Dose
Oral
Attention deficit hyperactivity disorder
Child: >6 yr <70 kg: Initially, 0.5 mg/kg/day, may increase gradually to approx 1.2 mg/kg/day. Max: 1.4 mg/kg or 100 mg, whichever is lower;
>70 kg: Initially, 40 mg/day, may increase gradually after at least 7 days to 80 mg/day, up to100 mg/day may be used after 2-4 wk.
Renal Dose
Renal impairment: Dosage adjustment not necessary
Administration
May be taken with or without food. Swallow whole, do not open cap. Administer once daily in morning, with or without food
Contra Indications
Angle-closure glaucoma. Not to be used with or within 14 days of discontinuing treatment with MAOIs.
Precautions
Monitor height and wt gain especially during the initial period of treatment; dose reduction or treatment interruption may be needed in children whose growth or wt gain is not satisfactory. Patients with high BP or cardiovascular conditions that may be worsened by increases in BP or heart rate. Caution when used in patients with a history of psychotic illness or bipolar disorder. May increase the risk of urinary obstruction or hesitancy. Monitor for signs of clinical worsening, suicidality or unusual behavioural changes especially during the start of treatment and during dose changes. Safety and efficacy have not been established in patients <6 yr. Not recommended for use in pregnancy.
Lactation: Unknown whether drug is excreted in milk; use with caution
Pregnancy-Lactation
Interactions
May cause additive effect when used w/ drugs that increase BP. May potentiate the effect of salbutamol on the CVS. May increase risk of cardiac events when used w/ drugs that affect cardiac conduction or electrolyte balance, or that inhibit CYP2D6 (e.g. fluoxetine, paroxetine, quinidine). Increased risk of QT prolongation w/ QT prolonging drugs (e.g. class Ia and III antiarrhythmics, moxifloxacin, erythromycin, TCAs, lithium, cisapride). Increased risk of seizures w/ drugs that are known to lower seizure threshold (e.g. phenothiazines, neuroleptics, mefloquine, bupropion, tramadol).
Potentially Fatal: Increased neurotoxic effect w/ MAOIs.
Adverse Effects
Side effects of Atomoxetine :
>10%
Xerostomia (dry mouth) (21%),Headache (2-19%),Abdominal pain (7-18%),Decreased appetite (11-16%),Insomnia (2-15%),Cough (11%),Somnolence (11%),Vomiting (3-11%)
1-10%
Nausea (10%),Increases in blood pressure (BP; ≥15-20 mm Hg) and heart rate (HR; ≥20 beats/min) (5-10%),Erectile dysfunction (9%),Hot flashes (8%),Dizziness (5-8%),Urinary hesitation or retention (7%),Decreased weight (4-7%),Depression (4-7%),Irritability (<6%),Dyspepsia (4%),Ejaculation disorder (3%),Sinus headache (3%),Constipation (2%),Dermatitis (2%),Menstrual disorder (2%),Mood swings (1-2%)
Mechanism of Action
Atomoxetine hydrochloride selectively inhibits noradrenaline reuptake w/ minimal affinity for other noradrenergic receptors or for other neurotransmitter receptors or transporters. It is used in the treatment of attention deficit hyperactivity disorder.
Note
Attentrol 18 18mg Capsule manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Atomoxetine. Attentrol 18 is availble in Nepal.
Farmaco Nepal drug index information on Attentrol 18 Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.