Avidro 0.5 Tablet

Pizotifen
0.5mg
Beximco Pharmaceuticals Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 3.48 NPR

Available as:

Indications

Avidro 0.5 Tablet is used for: Headache, Migraine

Adult Dose

Oral Prophylaxis of migraine; Prophylaxis of cluster headache Adult: Initially, 0.5 mg, increase gradually as necessary. Maintenance: 1.5 mg daily as a single dose at night or in 3 divided doses. Max: 4.5 mg daily (max ?3 mg/dose). Hepatic impairment: Dose adjustment may be needed.

Child Dose

Oral Prophylaxis of migraine; Prophylaxis of cluster headache Child: >2 yr Initially, 0.5 mg. May increase gradually up to 1.5 mg daily in divided doses (max 1 mg/dose).

Renal Dose

Renal impairment: Dose adjustment may be needed.

Administration

May be taken with or without food.

Contra Indications

Premature infants or neonates. Postural giddiness.

Precautions

Patient w/ angle-closure glaucoma, urinary retention, epilepsy. Avoid abrupt withdrawal. Renal and hepatic impairment. Childn. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness, somnolence and dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor hepatic function (prolonged use), wt gain, BP.

Pregnancy-Lactation

Interactions

Enhances sedative effects of CNS depressants. Additive antimuscarinic action with other antimuscarinic drugs. May mask warning signs of damage caused by ototoxic drugs eg, aminoglycosides.

Adverse Effects

Side effects of Pizotifen : Increased appetite, nausea, wt gain, drowsiness, dizziness, dry mouth, fatigue, muscle pain or cramps, heavy or restless legs, fluid retention, facial flushing, reduced libido, exacerbation of epilepsy, dreaming, hepatic injury.

Mechanism of Action

Pizotifen is a sedating antihistamine with strong serotonin antagonist and weak antimuscarinic properties. It also antagonises the action of tryptamine.

Note

Avidro 0.5 0.5mg Tablet manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Pizotifen. Avidro 0.5 is availble in Nepal. Farmaco Nepal drug index information on Avidro 0.5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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