Aztatin Tablet
Lovastatin
20mg
Sun Pharmaceutical Industries Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 10.19 NPR |
Available as:
Indications
Aztatin Tablet is used for:
Coronary Artery Disease, Hyperlipidaemias
Adult Dose
Oral
Hyperlipidaemias; Primary prophylaxis of coronary artery disease
Adult: Initially, 10-20 mg/day in the evening, may increase at intervals of at least 4 wk to max 80 mg/day as a single or in 2 divided doses.
Child Dose
Oral
Hyperlipidaemias; Primary prophylaxis of coronary artery disease
Child: As an adjunct w/ heterozygous familial hypercholesterolaemia: 10-17 yr Initially, 10-20 mg once daily, may increase at intervals of 4 wk to max 40 mg once daily.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Use w/ caution in doses >20 mg/day.
Administration
Should be taken with food.
Contra Indications
Active liver disease or unexplained persistent elevated serum transaminases. Concomitant use w/ CYP3A4 inhibitors (e.g. nefazodone, erythromycin, boceprevir, clarithromycin, telithromycin, HIV protease inhibitors, itraconazole, ketoconazole, posaconazole, telaprevir), gemfibrozil, ciclosporin. Pregnancy and lactation.
Precautions
History of liver disease; patients at risk of myopathy; alcoholism; inadequately controlled hypothyroidism. Severe renal impairment. Monitoring Parameters Monitor creatine kinase (CK) periodically and LFT. Discontinue if there is significant or persistent increase in CK levels, serum aminotransferase levels or evidence of myopathy.
Lactation: Contraindicated; unsafe
Pregnancy-Lactation
Interactions
Increased risk of myopathy/rhabdomyolysis w/ amiodarone, colchicine, ranolazine, danazol, diltiazem and verapamil. May increase anticoagulant effect of warfarin.
Potentially Fatal: Increased risk of myopathy and rhabdomyolysis w/ concomitant CYP3A4 inhibitors (e.g. nefazodone, erythromycin, boceprevir, clarithromycin, telithromycin, HIV protease inhibitors, itraconazole, ketoconazole, posaconazole, telaprevir), gemfibrozil, ciclosporin.
Adverse Effects
Side effects of Lovastatin :
>10%
CPK elevation (11%)
1-10%
Flatulence (4-5%),Abdominal pain (2-3%),Constipation (2-3%),Diarrhea (2-3%),Myalgia (2-3%),Nausea (2-3%),Dyspepsia (1-2%),Weakness (1-2%),Blurred vision (0.8-1%),Rash (0.8-1%),Muscle cramps (0.6-1%),Dizziness (0.5-1%)
<1%
Dermatomyositis,Increased LFTs,Hepatotoxicity,Myopathy,Rhabdomyolysis
Potentially Fatal: Rhabdomyolysis and acute renal failure.
Mechanism of Action
Lovastatin reduces cholesterol by competitively inhibiting HMG-CoA reductase, the rate-limiting step cholesterol biosynthesis.
Note
Aztatin 20mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Lovastatin. Aztatin is availble in Nepal.
Farmaco Nepal drug index information on Aztatin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.