Benadryl Syrup
Diphenhydramine Hydrochloride
100ml
Emcure Pharmaceuticals Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 65.42 NPR |
Indications
Benadryl Syrup is used for:
Allergic rhinitis, Allergic conditions, Motion sickness, Common cold, Insomnia, Extrapyramidal symptoms
Adult Dose
Oral
Allergic conditions; Treatment and prophylaxis of motion sickness
Adult: 25-50 mg 3-4 times daily. For prevention of motion sickness, admin 30 min before exposure to motion. Max: 300 mg daily.
Parkinson's disease
Adult: Initially, 25 mg tid, may increase to 50 mg 4 times daily if necessary.
Short-term management of insomnia
Adult: 50 mg 30 min before bedtime as needed.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Allergic Reaction
2-6 years: 6.25 mg q4-6hr; not to exceed 37.5 mg/day
6-12 years: 12.5-25 mg PO q4-6hr; not to exceed 150 mg/day
>12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day
Occasional Insomnia
>12 years: 50 mg PO 30 minutes before bedtime
Cough
<12 years: Safety and efficacy not established
>12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day
Motion Sickness
Administer 30 min before motion
12.5-25 mg PO q6-8hr or 150 mg/m² ; not to exceed 300 mg/day
Renal Dose
Renal impairment: No dosage adjustment needed.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity ; neonates, lactation.
Precautions
Epilepsy; elderly; performing tasks which require mental alertness; angle-closure glaucoma; pyroduodenal obstruction; urinary tract obstruction; hyperthyroidism; raised intraocular pressure; CV disease; acute asthma; pregnancy.
Lactation: Drug enters breast milk; contraindicated
Pregnancy-Lactation
Interactions
Masks ototoxicity produced by aminoglycosides. Increases gastric degradation of levodopa and decreases its absorption by reduction of gastric emptying. Antagonises therapeutic effects of cholinergic agents e.g. tacrine, donezepil and neuroleptics. Valerian, St. John's wort, Kava Kava and gotu kola may increase CNS depression.
Potentially Fatal: Potentiates CNS depression with alcohol, barbiturates, analgesics, sedatives and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and TCAs.
Adverse Effects
Side effects of Diphenhydramine Hydrochloride :
Chest tightness, extrasystoles, hypotension, palpitations, tachycardia; ataxia, chills, confusion, dizziness, drowsiness, euphoria, excitement, fatigue, headache, insomnia, irritability, nervousness, neuritis, paraesthesia, paradoxical excitation, restlessness, sedation, seizure, vertigo; diaphoresis; menstrual disease; GI disturbances (e.g. anorexia, constipation, diarrhoea); difficulty in micturition, urinary frequency, urinary retention; agranulocytosis, haemolytic anaemia, thrombocytopenia; anaphylactic shock; tremor; blurred vision, diplopia; acute labyrinthitis, tinnitus; constriction of pharynx, nasal congestion, thickening of bronchial secretions, wheezing;
Mechanism of Action
Diphenhydramine blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also causes sedation and has some anticholinergic action.
Note
Benadryl 100ml Syrup manufactured by Emcure Pharmaceuticals Ltd.. Its generic name is Diphenhydramine Hydrochloride. Benadryl is availble in Nepal.
Farmaco Nepal drug index information on Benadryl Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.