Bencid Tablet
Probenecid
Geno Pharmaceuticals Ltd.
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| Retail Price | 4.84 NPR |
Indications
Bencid Tablet is used for:
Hyperuricaemia with gout, Adjunct to antibacterial therapy
Adult Dose
Oral
Hyperuricaemia with gout
Adult: 250 mg bid for 1 wk, followed by 500 mg bid thereafter. Further increases of up to 2 g daily by increments of 500 mg every 4 wk may be given if needed.
Adjunct to antibacterial therapy
Adult: 500 mg 4 times daily. Treatment of uncomplicated gonorrhoea: 1 g as a single dose together w/ an oral antibacterial, or 30 min before an injected antibacterial.
Child Dose
Oral
Adjunct to antibacterial therapy
Child: >2 yr <50 kg: Initially, 25 mg/kg (700 mg/m2) followed by 40 mg/kg (1,200 mg/m2) in 4 divided doses.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Avoid use.
Administration
Should be taken with food. Take w/ meals or antacids. Ensure adequate fluid intake.
Contra Indications
History of uric acid renal calculi or blood disorders; gout patients w/ severe renal impairment. Antibacterial adjunct in patients w/ renal impairment. Childn <2 yr. Concomitant use w/ salicylates.
Precautions
Patient w/ history of peptic ulcer. Pregnancy and lactation. Patient Counselling Maintain adequate fluid intake (2-3 L/day). Monitoring Parameters Monitor uric acid, renal function, CBC.
Pregnancy-Lactation
Interactions
May potentiate methotrexate toxicity. May increase peak plasma concentrations of paracetamol, naproxen, indometacin, ketoprofen, meclofenamate, lorazepam, rifampicin, aciclovir, ganciclovir and zidovudine. May decrease the renal excretion of conjugated sulfonamides. May prolong or enhance the action of oral sulfonylureas thereby increasing the risk of hypoglycaemia. Pyrazinamide may antagonise the uricosuric action of probenecid.
Potentially Fatal: Salicylates antagonise the uricosuric action of probenecid.
Adverse Effects
Side effects of Probenecid :
1-10%
Headache
Nausea
Vomiting
Loss of appetite
GI upset
Rash
Flushing
Dizziness
Fever
Aplastic anemia
Hemolytic anemia
Leukopenia
Renal calculi
Nephrotic syndrome (rare)
Exacerbation of gout
Gouty arthritis
Hepatic necrosis (rare)
Mechanism of Action
Probenecid competitively inhibits the reabsorption of uric acid at the proximal convoluted tubule, thereby promoting its excretion and reducing serum uric acid levels. It increases plasma levels of weak organic acids (e.g. penicillins, cephalosporins, or other beta-lactam antibiotics) by competitively inhibiting their renal tubular secretion.
Note
Bencid Tablet manufactured by Geno Pharmaceuticals Ltd.. Its generic name is Probenecid. Bencid is availble in Nepal.
Farmaco Nepal drug index information on Bencid Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.