Betnovate C Ointment
Betamethasone 0.1% + Clotrimazole 1% Topical
Glaxo SmithKline Pharmaceuticals Ltd.
| Pack size | 20g |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 32.00 NPR |
Indications
Betnovate C Ointment is used for:
Tinea pedis, tinea cruris, tinea corporis, ringworm, athlete's foot, jock itch.
Adult Dose
Tinea Pedis, Tinea Cruris, & Tinea Corporis
Apply to infected area q12hr for 2 weeks for tinea cruris and tinea corporis; 4 weeks for tinea pedis
Allergic or Inflammatory Diseases
Apply to affected area in the morning and evening
Child Dose
<17 years: Safety and efficacy not established
Renal Dose
Administration
Contra Indications
Patients who are sensitive to clotrimazole, betamethasone dipropionate, other corticosteroids or imidazoles, or to any ingredient in these preparations.
Precautions
Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment.
Conditions which augment systemic absorption include use over large surface areas, prolonged use, and use under occlusive dressings.
If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid.
Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Betamethasone 0.1% + Clotrimazole 1% Topical :
1-10%
Dry skin (2%),Paresthesia (2%),Local burning (2%)
<1%
Edema,Rash,Skin atrophy,Secondary infection,Skin ulceration,Acneiform eruption,Bruising,Folliculitis,Striae
Clotrimazole
Erythema,Stinging,Blistering,Peeling,Edema,Pruritus,Urticaria,General skin irritation
Betamethasone
Burning,Itching,Irritation,Dryness,Folliculitis,Hypertrichosis,Acneiform eruptions,Hypopigmentation,Perioral dermatitis,Allergic contact dermatitis,Skin maceration,Skin atrophy,Striae,Miliaria,HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.
Clotrimazole is an antifungal agent that binds to phospholipids in the fungal cell membrane. It causes loss of essential intracellular components by altering cell wall permeability.
Note
Betnovate C Ointment manufactured by Glaxo SmithKline Pharmaceuticals Ltd.. Its generic name is Betamethasone 0.1% + Clotrimazole 1% Topical. Betnovate C is availble in Nepal.
Farmaco Nepal drug index information on Betnovate C Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.