Bioposide Injection

Etoposide
100mg
Biochem Pharmaceuticals Industries Limited.
Pack size
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Source
Agent
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Indications

Bioposide Injection is used for: Lung cancer, Testicular cancer

Adult Dose

Intravenous Testicular Cancer 50-100 mg/m²/day IV on days 1-5, OR 100 mg/m²/day IV on days 1, 3, 5 Repeat q3-4week Small-Cell Lung Cancer 35 mg/m²/day IV for 4 days, OR 50 mg/m²/day IV for 5 days; repeat q3-4week Oral Small cell lung cancer Adult: Twice the IV dose, rounded to the nearest 50 mg.

Child Dose

Renal Dose

Renal Impairment CrCl >50 mL/min: Dose adjustment not necessary CrCl 15-50 mL/min: 75% of regular dose CrCl < 15 mL/min: Not studied; consider further dose reductions

Administration

Contra Indications

Hypersensitivity, pregnancy, lactation.

Precautions

Skin reactions may occur with accidental exposure; renal or hepatic disease. Periodic CBCs should be done before, during and after therapy. Increased risk of etoposide-toxicity in patients with low serum albumin. Acrylic material has been shown to crack and leak when used with undiluted etoposide inj. Lactation: not known if excreted in breast milk, discontinue drug or do not nurse

Pregnancy-Lactation

Interactions

Synergism with other cytotoxic drugs. Caution when admin with drugs that inhibit phosphatase activity. Cyclosporin A may reduce the clearance of etoposide.

Adverse Effects

Side effects of Etoposide : >10% Leukopenia (60-91%),Nausea and Vomiting (30-40%),Thrombocytopenia (28-41%),Alopecia (20-90%),Anorexia (13%),Diarrhea (13%),Leukopenia (60-91%),Anemia (≤33%) 1-10% Pancytopenia (7%),Stomatitis (6%),Hepatic toxicity (3%),Type 1 hypersensitivity (2%),Orthostatic hypotension (1-2%),Peripheral neuropathy (1-2%) Frequency Not Defined Malaise,Shivering,Asthenia,Fever,Mucous membrane inflammation,Hyperuricemia,Local soft tissue toxicity has been reported following extravasation; see section on IV information for extravasation management Potentially Fatal: Severe myelosuppression, characterised by leucopaenia and thrombocytopaenia. Cardiotoxicity. Anaphylaxis.

Mechanism of Action

Etoposide is a derivative of podophyllotoxin that inhibits DNA synthesis resulting in the arrest of the cell cycle. At low doses, it inhibits cells from entering cell cycle and at high doses, cells entering mitosis are lysed.

Note

Bioposide 100mg Injection manufactured by Biochem Pharmaceuticals Industries Limited.. Its generic name is Etoposide. Bioposide is availble in Nepal. Farmaco Nepal drug index information on Bioposide Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Etoposide :