Biotex 1 Injection
Cefotaxime
1gm
Biochem Pharmaceuticals Industries Limited.
| Pack size | 1 |
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Available as:
Indications
Biotex 1 Injection is used for:
Pneumonia, Meningitis, Peritonitis, Pelvic inflammatory disease, Endometritis, Pelvic cellulitis, Gonorrhea, Skin and skin structure infections, Respiratory tract infections, Urinary tract infections, Bacteremia/Septicemia, Bone and/or joint infections
Adult Dose
Adult:
Infections Caused by Susceptible Organisms
Uncomplicated: 1 g IV or IM q12hr
Moderate to severe: 1-2 g IV or IM q8hr
More serious (bloodstream infection [septicemia]): 2 g IV q6-8hr
Life-threatening: 2 g IV q4hr; not to exceed 12 g/day
Surgical prophylaxis 1 g 30-90 mins before procedure.
Gonorrhoea 0.5-1 g as a single dose.
Child Dose
Children: IV, IM 50–180 mg/kg/day q6–8h
200–225 mg/kg/day for meningitis q6h
Neonates:
The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses. In severe infections 150-200 mg/kg/day in divided doses have been given.
Renal Dose
Renal impairment: Severe: After an initial loading dose of 1 g, half the daily dose w/o changing the frequency.
Administration
IV Preparation
Intermittent injection: Reconstitute 1 or 2 g with 10 mL SWI
Infusion: Reconstitute infusion bottles with 50 or 100 mL NS or D5W
IM: Add 2 mL, 3 mL or 5 mL of sterile or bacteriostatic water for inj to a vial
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
History of penicillin allergy; colitis; impaired renal function; pregnancy, lactation.
Lactation: Drug enters breast milk; use with caution
Pregnancy-Lactation
Interactions
Probenecid decreases cefotaxime elimination.
Potentially Fatal: Nephrotoxicity with furosemide and aminoglycosides.
Adverse Effects
Side effects of Cefotaxime :
Colitis, Elevated blood urea nitrogen (BUN) and creatinine, Elevated hepatic transaminases, Fever. Pain at inj site; hypersensitivity reactions, rash, pruritus; diarrhoea, nausea, vomiting; candidiasis; eosinophilia, neutropenia, leucopenia, thrombocytopenia.
Potentially Fatal: Anaphylactic reaction; nephrotoxicity.
Mechanism of Action
Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Biotex 1 1gm Injection manufactured by Biochem Pharmaceuticals Industries Limited.. Its generic name is Cefotaxime. Biotex 1 is availble in Nepal.
Farmaco Nepal drug index information on Biotex 1 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.