Briptin 2.5 Tablet
Bromocriptine
2.5mg
Martin & Harris
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 52.80 NPR |
Available as:
Indications
Briptin 2.5 Tablet is used for:
Parkinson's disease, Galactorrhoea; Hypogonadism; Infertility, acromegaly, Lactation suppression, benign breast and menstrual disorders, Amenorrhea, hyperprolactinaemia
.
Adult Dose
Adult: PO Parkinson's disease As adjunct to levodopa: 1st wk: 1-1.25 mg at night, 2nd wk: 2-2.5 mg at night; 3rd wk: 2.5 mg twice daily; 4th wk: 2.5 mg 3 times/day, then increase as needed.
Maintenance: 10-40 mg/day.
Hyperprolactinemia
Initial: 1.25-2.5 mg PO qDay
May increase by 2.5 mg/day q2-7Days
Usual therapeutic dosage 5-7.5 mg/day, ranges from 2.5-15 mg/day
Up to 30 mg/day has been used in some patients with amenorrhea &/or galactorrhea
Acromegaly (Parlodel)
1.25-2.5 mg PO qHS for 3 days
May increase by 1.25-2.5 mg/day at q3-7Days
Not to exceed 100 mg/day
Adjunct to surgery and radiotherapy in patients w/ acromegaly Initial: 2.5 mg twice daily, increase slowly, up to 5 mg 6 hrly if needed. Lactation suppression 2.5 mg/day for 2-3 days, up to 2.5 mg twice daily for 14 days.
Prevention of puerperal lactation 2.5 mg on the day of delivery, then 2.5 mg twice daily for 14 days. Cyclical benign breast and menstrual disorders 2.5 mg twice daily.
Hepatic Impairment: Dose adjustment may be necessary; there are no guidelines
Child Dose
Hyperprolactinemia
11-15 years: 1.25-2.5 mg PO qDay (initially)
Maintenance: 2.5-10 mg/day
Renal Dose
Administration
Should be taken with food.
Contra Indications
Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease. Pregnancy and lactation.
Precautions
Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired.
Lactation: should not be used during lactation
Pregnancy-Lactation
Interactions
Bioavailability increased if given along with erythromycin. Alcohol reduces tolerance to bromocriptine and vice-versa. Effects of antihypertensives may be potentiated. Avoid concurrent psychotropics.
Adverse Effects
Side effects of Bromocriptine :
>10%
Nausea (49%),Hypotension (30%),Headache (19%),Dizziness (17%)
1-10%
Abdominal cramps,Anorexia,Constipation,Dyspepsia,Dysphagia,Epigastric pain,GI hemorrhage,Vomiting,Drowsiness,Fatigue,Faintness,Hallucinations Visual,Insomnia,Lightheadedness,Nighmares,Paranoia,Psychosis,Seizure,Vertigo,Arrhythmias,Bradycardia,Hypertension,MI,Mottled skin,Orthostasis,Vasospasm,Palpitations,Pericardial effusions,Raynaud's syndrome exacertabtion,Syncope,Blepharospasm,BUN increased,Burning discomfort of the eye,Diplopia,Facial pallor,Leg cramps,Nasal congestion,Rash,Urticaria
Mechanism of Action
Bromocriptine is a dopamine D2 and D3-agonist which works by activating postsynaptic dopamine receptors in the tuberoinfundibular and nigrostriatal pathways. It also inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and in endocrinological disorders.
Note
Briptin 2.5 2.5mg Tablet manufactured by Martin & Harris. Its generic name is Bromocriptine. Briptin 2.5 is availble in Nepal.
Farmaco Nepal drug index information on Briptin 2.5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.