C-Xelocel Tablet
Capecitabine
500mg
Celon Lab
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| Retail Price | 240.00 NPR |
Indications
C-Xelocel Tablet is used for:
Breast cancer, Colorectal cancer, Gastric cancer, Oesophageal cancer
Adult Dose
Oral
Breast cancer; Colorectal cancer
Adult: 1.25 g/m2 bid for 2 wk followed by a 1 wk rest period; therapy to be given in 3-wk cycles. Recommended treatment duration for colorectal cancer: 6 mth. May be used in combination with docetaxel at 75 mg/m2, given as a 1-hr IV infusion once every 3 wk for the treatment of breast cancer.
Gastric cancer
Adult: Used in combination with a platinum-based compound, 1 g/m2 bid for 14 days, followed by a 7-day rest period. 1st dose is given on the evening of day 1 and the last dose on the morning of day 15.
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min)
51-80 No adjustment needed.
30-50 Reduce dose to 950 mg/m2 bid when starting dose is 1.25 g/m2 bid. No dose adjustment is needed when starting dose is 1 g/m2.
<30 Avoid use.
Administration
Swallow with water within 30 min after a meal
Contra Indications
History of severe and unexpected reactions to fluoropyrimidine therapy; severe renal impairment; pregnancy, lactation. Hypersensitivity.
Precautions
Hepatic dysfunction, bone marrow suppression, poor nutritional status, warfarin therapy. Child, elderly, prior extensive pelvic radiation or alkylating therapy. Moderate renal impairment; CBC with differential; monitor hepatic and renal function. Discontinue use if intractable diarrhoea, stomatitis, bone marrow suppression or MI develops.
Pregnancy-Lactation
Interactions
Antacids containing aluminum and magnesium, leucovorin, anticoagulants, phenytoin, allopurinol.
Adverse Effects
Side effects of Capecitabine :
10%
Diarrhea,Nausea,Anemia,Lymphopenia,Hand and foot syndrome,Edema,Fatigue,Fever,Headache,Pain,Paresthesia,Alopecia,Dermatitis,Abdominal pain,Anorexia,Appetite decreased,Constipation,Dyspepsia,Stomatitis,Vomiting,Neutropenia,Thrombocytopenia,Dyspnea,Bilirubin increased,Eye irritation
1-10%
Chest pain,Dermatitis,Pruritus,Rash,Dizziness,Headache,Weakness,Dehydration,Dry mouth,Dyspepsia,Taste disturbance,Back pain
Potentially Fatal: Cardiotoxicity, bone-marrow depression and hyperbilirubinaemia.
Mechanism of Action
Capecitabine is a prodrug that is converted to fluorouracil following oral administration, which in turn inhibits thymidylate synthetase, blocking the methylation of deoxyuridylic acid to thymidylic acid, interfering with DNA, and to a lesser degree, RNA synthesis.
Note
C-Xelocel 500mg Tablet manufactured by Celon Lab. Its generic name is Capecitabine. C-Xelocel is availble in Nepal.
Farmaco Nepal drug index information on C-Xelocel Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.