CEFROM Injection
Cefpirome
1.0GM
Aventis Pharma Limited.
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| Retail Price | 1190.00 NPR |
Indications
CEFROM Injection is used for:
Susceptible infections
Adult Dose
Intravenous
Susceptible infections
Adult: As sulfate: 1-2 g every 12 hrly
Child Dose
Renal Dose
Renal impairment: Loading dose: 1-2 g followed by a maintenance dose adjusted according to CrCl.
CrCl (ml/min)
20-50 0.5-1 g bid.
5-20 0.5-1 g once daily.
<5 (in haemodialysis patients) 0.5 or 1 g once daily with half-dose after each dialysis session.
Administration
IV Administration
Administer by IV inj over 3-5 min, OR
By intermittent infusion over 20-30 min
Contra Indications
Hypersensitivity; porphyria.
Precautions
Allergy to penicillin or to cephalosporins; renal impairment, monitor renal and haematological status; pregnancy and lactation.
Lactation: excreted in breast milk; unsure if safe; do not use
Pregnancy-Lactation
Interactions
Reduced clearance with probenecid.
Adverse Effects
Side effects of Cefpirome :
<1%
Colitis,Diarrhea,Dyspnea,Headache,Phlebitis,Rash,Vaginitis,Vomiting
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Cefpirome binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
CEFROM 1.0GM Injection manufactured by Aventis Pharma Limited.. Its generic name is Cefpirome. CEFROM is availble in Nepal.
Farmaco Nepal drug index information on CEFROM Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.