Centwin Suspention
Dicyclomine
10mg
Centaur Pharmaceuticals Pvt. Ltd.
| Pack size | 10ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 21.18 NPR |
Indications
Centwin Suspention is used for:
Irritable Bowel Syndrome
Adult Dose
Irritable Bowel Syndrome
20 mg PO q6hr; may increase up to 40 mg q6hr; if efficacy not achieved in 2 weeks or adverse effects require dose <80 mg/day, therapy should be discontinued; safety data not available for doses > 80 mg/day for periods > 2 weeks
Child Dose
Irritable Bowel Syndrome
Infants >6 months: 5 mg PO q6-8hr; not to exceed 20 mg/day PO
Children: 10 mg PO q6-8hr; not to exceed 40 mg/day PO
Renal Dose
Administration
Take 30-60 minutes before a meal
Contra Indications
Hypersensitivity to dicyclomine or any anticholinergic drugs
Closed-angle glaucoma, Myasthenia gravis, Hemorrhage with cardiovascular instability, Paralytic ileus, Breast feeding, Intestinal atony of elderly/debilitated patients, Toxic megacolon, GI obstruction, Obstructive uropathy
Severe ulcerative colitis, Reflux esophagitis, Infants aged <6 months (reports of seizure, respiratory failure, death)
Precautions
Caution in renal/hepatic impairment, benign prostatic hyperplasia, congestive heart failure, tachycardia secondary to cardiac insufficiency or thyrotoxicosis, hypertension, coronary artery disease, chronic obstructive pulmonary disease, hiatal hernia, mitral stenosis, brain damage or spastic paralysis in children, salivary secretion disorder, down syndrome, autonimic neuropathy, hyperthyroidism, Tachyarrhythmia; assess before administration, Use caution in patients with mild-moderate ulcerative colitis, Effects may be potentiated when used with other sedative drugs or ethanol, Serious respiratory reactions, CNS symptoms, and deaths reported following administration to infants
Lactation: Enters breast milk; contraindicated
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dicyclomine :
>10%
Dizziness (40%), Xerostomia (33%), Blurred vision (27%)
1-10%
Somnolence (9%), Nervousness (6%), Weakness (7%)
Frequency Not Defined
Abdominal distension,Confusional state,Cycloplegia,Delirium,Dermatitis,Erythema,Fatigue,Hallucinations,Insomnia,Malaise,Palpitation,Rash,Syncope
Mechanism of Action
Anticholinergic/antispasmodic; no effect on acid secretion, but direct smooth muscle relaxant effects; blocks the action of ACh at parasympathetic sites in smooth muscle, secretory glands, and CNS
Note
Centwin 10mg Suspention manufactured by Centaur Pharmaceuticals Pvt. Ltd.. Its generic name is Dicyclomine. Centwin is availble in Nepal.
Farmaco Nepal drug index information on Centwin Suspention is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.