Cipad Tablet
Cisapride
10mg
Curex Pharmaceuticals Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 4.60 NPR |
Indications
Cipad Tablet is used for:
Gastrointestinal Dysmotility
Adult Dose
Gastrointestinal Dysmotility
5-10 mg PO q6hr
May need to increase to 20 mg in some patients
Child Dose
Gastrointestinal Dysmotility
0.15-0.3 mg/kg/dose PO q6-8hr; not to exceed 10 mg/dose
Renal Dose
Administration
Contra Indications
Hypersensitivity
Serious cardiac arrhythmias (eg, ventricular fibrillation, torsades de pointes, and QT prolongation) reported in patients taking cisapride with other drugs that inhibit cytochrome CYP3A4 or have additive QT prolonging effect; some of these events have been fatal
Patient history or family history of prolonged QT syndrome
History of renal failure, ventricular arrhythmias, ischemic heart disease, CHF, clinically significant bradycardia, uncorrected electrolyte disorders (eg, hypomagnesemia, hypokalemia), and respiratory failure
Precautions
Lactation: enters breast milk; use with caution (AAP Committee states compatible with nursing)
Pregnancy-Lactation
Interactions
Concomitant drugs known to prolong QT and increase risk of arrhythmia (eg, class III antiarrhymic agents, CYP3A4 inhibitors by elevating cisapride drug levels, drugs that decrease serum levels of potassium or magnesium).
Contraindicated with numerous drugs including those known to cause QT prolongation (eg, tricyclics, certain antipsychotics) or CYP450 3A4 inhibitors (eg, fluconazole, ketoconazole, itraconazole).
Adverse Effects
Side effects of Cisapride :
>10%
Headache,Diarrhea
1-10%
Abdominal pain,Constipation,Tachycardia,Rash,Somnolence,Fatigue,Anxiety,Insomnia,Extrapyramidal effects,Nausea,Sinusitis,Rhinitis,Upper respiratory tract infection,Increased incidence of viral infection
<1%
Bronchospasm,Gynecomastia,Hyperprolactenemia,Methemoglobinemia,Seizure,Psychiatric disturbances,Apnea
Mechanism of Action
Promotes gastric emptying, increases lower esophageal sphincter tone and esophageal peristalsis
Increases gastric motility and cardiac rate possibly by releasing acethylcholine at the myenteric plexus; may act at the serotonin-4 receptor
Note
Cipad 10mg Tablet manufactured by Curex Pharmaceuticals Pvt. Ltd.. Its generic name is Cisapride. Cipad is availble in Nepal.
Farmaco Nepal drug index information on Cipad Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.