Cizodol P 1.5/2 Tablet

Haloperidol + Trihexyphenidyl (Benzhexol)
1.5mg + 2mg
Asian Pharmaceuticals Pvt. Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 2.50 NPR

Available as:

Indications

Cizodol P 1.5/2 Tablet is used for: Psychoses, Parkinsonism

Adult Dose

Oral Psychoses, Parkinsonism Adult: 1-2 tab 2-3 times daily

Child Dose

Renal Dose

Administration

May be taken with or without food. May be taken w/ meals to minimise GI irritation.

Contra Indications

Severe toxic CNS depression; preexisting coma;

Precautions

Epilepsy, allergy, angle-closure glaucoma, benign prostatic hyperplasia; severe cardiac or hepatic disease; extremes in temp (hot and cold weather); presence of acute infections or leucopenia; hyperthyroidism; pregnancy, elderly, children.Patient w/ arteriosclerosis, history of drug idiosyncrasy. CV disease, glaucoma, GI obstruction, prostatic hyperplasia and/or urinary stricture.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Haloperidol + Trihexyphenidyl (Benzhexol) : Anxiety, drowsiness, depression, anorexia, transient tachycardia, postural hypotension, leukopenia; anticholinergic side effects. Dryness of the mouth, nausea, constipation, vomiting, dizziness, drowsiness, headache, blurred vision, mydriasis, nervousness, tachycardia, urinary hesitancy or retention, increased intraocular tension, angle-closure glaucoma, weakness, rashes, dilatation of the colon, paralytic ileus, and suppurative parotitis. Potentially Fatal: Neuroleptic malignant syndrome.

Mechanism of Action

Haloperidol blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It produces calmness and reduces aggressiveness with disappearance of hallucinations and delusions. Trihexyphenidyl HCl is a tertiary amine antimuscarinic which exerts a direct inhibitory effect on the parasympathetic nervous system. It also exhibits a direct spasmolytic action on smooth muscle, weak mydriatic, antisialagogue and cardiovagal blocking effects.

Note

Cizodol P 1.5/2 1.5mg + 2mg Tablet manufactured by Asian Pharmaceuticals Pvt. Ltd.. Its generic name is Haloperidol + Trihexyphenidyl (Benzhexol). Cizodol P 1.5/2 is availble in Nepal. Farmaco Nepal drug index information on Cizodol P 1.5/2 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Haloperidol + Trihexyphenidyl (Benzhexol) :