Clinace Gel Gel
Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical
1.0% + 0.025%
Maruti Pharma Pvt. Ltd.
| Pack size | 15 gm |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 114.98 NPR |
Indications
Clinace Gel Gel is used for:
Acne vulgaris
Adult Dose
Acne Vulgaris
Topical
Apply a pea-size amount of gel once daily preferably at bed time.
Treatment should be continued for 12 weeks.
Child Dose
<12 years old: Safety and efficacy not established
>12 years: Apply a pea-size amount of gel once daily preferably at bed time.
Renal Dose
Administration
At first wash the face or affected area gently with warm water or soap.
When the skin is completely dried (about 30 minutes later) apply a pea-size amount of gel to your fingertip and spread it over your face.
Contra Indications
Contraindicated in patients with hypersensitivity to clindamycin or tretinoin or any of the ingredients of these medicine.
Precautions
Clindacin plus gel is not for oral, ophthalmic, or Intravaginal use.
Avoid exposure to sunlight and sunlamps. Wear sunscreen daily.
Lactation: excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Clindamycin: May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione).
Tretinoin: Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides.
Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.
Adverse Effects
Side effects of Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical :
>10%
Erythema (21-35%),Scaling (13-19%),Itching (15-17%)
1-10%
Dryness (6%),Irritation (5%),Exfoliation (5%),Erythema (4%),Pruritus (2%),Stinging (2%),Burning (2%),Sunburn (1%),Dermatitis (1%)
Mechanism of Action
Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown
Tretinoin: Exact mechanism unknown; appears to cohesiveness of follicular epithelial cells with decrease microcomedo formation; also increases turnover of follicular cells to cause extrusion of comedones
Note
Clinace Gel 1.0% + 0.025% Gel manufactured by Maruti Pharma Pvt. Ltd.. Its generic name is Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical. Clinace Gel is availble in Nepal.
Farmaco Nepal drug index information on Clinace Gel Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.