Clindex 2.5 Tablet
Chlordiazepoxide + Clidinium
National Healthcare Pvt. Ltd.
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Indications
Clindex 2.5 Tablet is used for:
Irritable bowel syndrome
Adult Dose
Oral
Irritable bowel syndrome
Adult: Each capsule containing chlordiazepoxide 5 mg and clidinium 2.5 mg: 1-2 capsule 3-4 times a day, before meals and at bedtime.
Elderly: Minimal effective dose.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Should be taken on an empty stomach. Take ½-1 hr before meals.
Contra Indications
Hypersensitivity
Glaucoma
Prostatic hypertrophy
Benign bladder neck obstruction
Severe respiratory depression
Precautions
Driving, hazardous work, elderly, renal disease, hepatic disease, hypertension, CVS disease, ulcerative colitis, hernia, reflux esophagitis, elderly and debilitated, autonomic neuropathy.
Lactation: Distributed in breast milk, avoid use; anticholinergic agents are known to inhibit lactation
Pregnancy-Lactation
Interactions
Cimetidine increases T1/2 of chlordiazepoxide. Absorption of chlordiazepoxide enhanced by metoclopramide and aluminum hydroxide. Chlordiazepoxide absorption hindered by Mg trisilicate, morphine and pethidine. Clidinium faces additive anticholinergic effects with antidepressants, quinidine and some antihistamines.
Potentially Fatal: Alcohol potentiates chlordiazepoxide and concurrent use of both can be potentially dangerous.
Adverse Effects
Side effects of Chlordiazepoxide + Clidinium :
Mouth dryness, blurring, hesitancy and urgency in micturition, constipation, rise in body temperature, heat stroke, tachycardia, mydriasis, headache, nervousness, drowsiness, weakness, nausea, aggression, dependence, mild skin rashes and impaired psychomotor performance.
Potentially Fatal: Severe hypersensitive reaction, hemolytic anemia (rarely).
Mechanism of Action
Chlordiazepoxide: Benzodiazepine; depresses all levels of CNS, including limbic and reticular formation, possibly by increasing gamma-aminobutyric acid (GABA) activity, a major inhibitory neurotransmitter
Clidinium: Anticholinergic agent; elicits antispasmodic and antisecretory effects on GI tract
Note
Clindex 2.5 Tablet manufactured by National Healthcare Pvt. Ltd.. Its generic name is Chlordiazepoxide + Clidinium. Clindex 2.5 is availble in Nepal.
Farmaco Nepal drug index information on Clindex 2.5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.