Clobetasol N Cream
Clobetasol Propionate 0.5% + Neomycin Sulphate 0.5% Topical
S.R. Drug Laboratories Pvt. Ltd.
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Indications
Clobetasol N Cream is used for:
Psoriasis, Eczema, Severe inflammatory skin disorders
Adult Dose
Topical/Cutaneous
Severe inflammatory skin disorders
Adult: As cream/ointment. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.
Child Dose
Topical/Cutaneous
Severe inflammatory skin disorders
Child: >2 yr: As cream/ointment. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.
Renal Dose
Administration
Apply sparingly to the affected area once or twice daily until improvement occurs. As with other highly active topical steroid preparations therapy should be discontinued when control is achieved.
Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient's condition being reviewed.
Contra Indications
Long-term treatment of ulcerative conditions, rosacea, pruritus; presence of acute infections. Hypersensitivity.
Precautions
Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye. If used in psoriasis careful patient supervision is important. Scalp Application: Keep away from eye. Flammable. Do not use or dry the hair near a fire or flame.
Pregnancy-Lactation
Interactions
If there is substantial systemic absorption, neomycin may prolong and intensify respiratory depressant effects of neuromuscular blockers.
Adverse Effects
Side effects of Clobetasol Propionate 0.5% + Neomycin Sulphate 0.5% Topical :
Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura.
Potentially Fatal: Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension.
Mechanism of Action
Clobetasol Propionate is a highly active corticosteroid that has topical anti-inflammatory action brought about partly by vasoconstriction and reduced collagen synthesis.
Neomycin is an aminoglycoside antibiotic that binds to ribosomal 30S and 50S subunits of susceptible bacteria, thus inhibiting protein synthesis; it also causes misreading of the genetic codes on the mRNA template.
Note
Clobetasol N Cream manufactured by S.R. Drug Laboratories Pvt. Ltd.. Its generic name is Clobetasol Propionate 0.5% + Neomycin Sulphate 0.5% Topical. Clobetasol N is availble in Nepal.
Farmaco Nepal drug index information on Clobetasol N Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.