Clofozine 50 Tablet
Clofazimine
50mg
Astra Zeneca
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 1.98 NPR |
Available as:
Indications
Clofozine 50 Tablet is used for:
Leprosy
Adult Dose
Dapsone-sensitive multibacillary leprosy
50 mg PO qDay in combination with dapsone 100 mg/day and rifampicin 600 mg/day
Administer for at least 2 years and continued, if possible, until negative skin smears are obtained
At this time, monotherapy with an appropriate antileprosy drug can be instituted
Dapsone-resistant leprosy
100 mg PO qDay in combination with 1 or more other antileprosy drugs for 3 years, followed by monotherapy with 100 mg of clofazimine daily
Child Dose
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity. Lactation.
Precautions
Pregnancy. Patients with GI symptoms.
Lactation: Distributed in human breast milk; do not administer to breastfeeding women unless clearly indicated
Pregnancy-Lactation
Interactions
Dapsone
Concomitant use of dapsone and clofazimine does not have a clinically important effect on dapsone pharmacokinetics.
Some evidence suggests dapsone may decrease or nullify some anti-inflammatory effects of clofazimine and theoretically might adversely affect clofazimine’s efficacy in patients with ENL reactions; several borderline leprosy and lepromatous leprosy patients with severe, recurrent ENL reactions reportedly required higher clofazimine dosage to control these reactions when dapsone therapy was given concomitantly than when clofazimine was given alone.
Isoniazid
Possible increased clofazimine plasma and urine concentrations and decreased clofazimine skin concentrations.
Rifampin
Although one study indicated that concomitant use of clofazimine in leprosy patients receiving rifampin alone or in conjunction with dapsone may decrease plasma concentrations and AUC of rifampin, concomitant use of clofazimine in another study in lepromatous leprosy patients receiving dapsone (100 mg daily) and rifampin (600 mg daily) did not affect rifampin pharmacokinetics.
Adverse Effects
Side effects of Clofazimine :
Well tolerated when dose does not exceed 100 mg/day
>10%
Skin discoloration (75-100%)
Gastrointestinal: Abdominal and epigastric pain, diarrhea, nausea, vomiting, GI intolerance (40%-50%)
Ichthyosis and dry skin (8-28%)
1-10%
Rash and pruritus (1-5%)
Ocular: Conjunctival and corneal pigmentation due to crystal deposits, dryness, burning, itching, irritation (>1%)
Discoloration of urine, feces, sputum, sweat (>1%)
Increased blood glucose (>1%) Increased ESR (>1%)
<1%
Skin: Phototoxicity, erythroderma, acneiform eruptions, monilial cheilosis
Body fluid discoloration and other skin reactions
Gastrointestinal: Bowel obstruction, GI bleeding, anorexia, constipation, weight loss, hepatitis, jaundice, eosinophilic enteritis, enlarged liver
Ocular: Diminished vision
Nervous: Dizziness, drowsiness, fatigue, headache, giddiness, neuralgia, taste disorder
Psychiatric: Depression secondary to skin discoloration
Laboratory: Elevated levels of albumin, serum bilirubin, and AST (SGOT), eosinophilia, hypokalemia
Ocular: Addition of maculopathy (bull’s eye retinopathy)
Other: Splenic infarction, thromboembolism, anemia, cystitis, bone pain, edema, fever, lymphadenopathy, vascular pain
Potentially Fatal: Crystal depletion in the wall of small bowel mesenteric lymph nodes, liver and spleen. Severe abdominal symptoms including bowel obstruction, GI bleeding and splenic infarction.
Mechanism of Action
Clofazamine inhibits mycobacterial growth by binding preferentially to mycobacterial DNA. It also has some anti-inflammatory activity.
Note
Clofozine 50 50mg Tablet manufactured by Astra Zeneca. Its generic name is Clofazimine. Clofozine 50 is availble in Nepal.
Farmaco Nepal drug index information on Clofozine 50 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.