Clopirel 150 Tablet
Clopidogrel
150mg
Nepal Pharmaceuticals Pvt. Ltd.
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Available as:
Indications
Clopirel 150 Tablet is used for:
Coronary Artery Disease, Acute coronary syndrome, Myocardial infarction, Peripheral vascular disease, Cerebrovascular disease, Atherosclerosis, Thromboembolic disorders, Unstable angina, Stroke
Adult Dose
Oral
Prophylaxis of thromboembolic disorders, Recent MI, Stroke, or Established Peripheral Arterial Disease, Coronary Artery Disease
Adult: 75 mg once daily.
Acute coronary syndrome
Adult: For ST-elevation MI: In combination w/ aspirin: 75 mg once daily.
<75 years
300 mg loading dose followed by 75 mg for 14 days up to 12 months (if no bleeding)
Concomitant therapy with aspirin: Administer in combination with aspirin 75-325 mg qDay with or without thrombolytics
>75 years
No loading dose
75 mg for 14 days up to 12 months (if no bleeding)
For unstable angina, non-ST-elevation MI: In combination w/ aspirin: Initially, 300 mg loading dose, followed by 75 mg once daily for up to 12 mth.
Hepatic impairment: Use caution; experience limited
Child Dose
Renal Dose
Renal impairment: Dose adjustment not necessary
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Active pathological bleeding. admin within 7 days after MI and ischaemic stroke, coagulation disorders. Lactation.
Precautions
Patients at risk of increased bleeding from trauma, surgery, or other pathological conditions; ulcer; renal and hepatic impairment; history of bleeding or haemostatic disorders. Pregnancy.
Lactation: Not known whether drug is excreted in breast milk; not recommended
Pregnancy-Lactation
Interactions
Co-admin with NSAIDs may increase the risk of stomach and intestinal bleeding. High-dose clopidogrel may lead to increased warfarin levels thus increasing the risk of bleeding. High-dose clopidogrel may also inhibit P450 (2C9), thus interfering with the metabolism of phenytoin, tamoxifen, torasemide, fluvastatin and some NSAIDs. Avoid c
Adverse Effects
Side effects of Clopidogrel :
1-10%
Upper respiratory tract infection (8.7%),Chest pain (8.3%),Headache (7.6%),Flulike syndrome (7.5%),Arthralgia (6%),Pain (6%),Dizziness (6%),Diarrhea (4.5%),Rash (4.2%),Rhinitis (4.2%),Depression (3.6%),Urinary tract infection (3.1%)
<1%
Severe neutropenia,Thrombotic thrombocytopenic purpura,Acute liver failure,Aplastic anemia,Hypotension,Hepatitis,Myalgia,Eczema,Erythema,Agranulocytosis
Potentially Fatal: Bleeding disorders including GI and intracranial haemorrhage. Blood dyscrasias.
Mechanism of Action
Clopidogrel inhibits adenosine diphosphate (ADP) from binding to its receptor sites on the platelets and subsequent activation of glycoprotein GP IIb/IIIa complex thus preventing fibrinogen binding, platelet adhesion and aggregation.
Note
Clopirel 150 150mg Tablet manufactured by Nepal Pharmaceuticals Pvt. Ltd.. Its generic name is Clopidogrel. Clopirel 150 is availble in Nepal.
Farmaco Nepal drug index information on Clopirel 150 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.