Codophos Tablet
Codeine
15mg
Vijayadeep Laboratories Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 7.00 NPR |
Available as:
Indications
Codophos Tablet is used for:
Mild to moderate pain, Cough suppression
Adult Dose
Oral
Mild to moderate pain
Adult: 15-60 mg 4 hrly. Max: 360 mg/day.
Cough suppression
Adult: 15-30 mg 3-4 times daily.
Child Dose
Oral
Mild to moderate pain
Child: <12 yr 0.5-1 mg/kg every 4-6 hr daily. Max: 240 mg daily.
Cough suppression
Child: 2-5 yr 3 mg; 6-12 yr 7.5-15 mg. Doses to be taken 3-4 times daily.
Renal Dose
Renal impairment: Dose adjustment may be needed.
Administration
May be taken with or without food.
Contra Indications
Respiratory depression; obstructive airway disease; acute and severe asthma attack; presence or suspicion of paralytic ileus, acute ulcerative colitis, antibiotic-associated colitis; comatose patients; acute alcoholism. Patients w/ head injury, raised intracranial pressure. Use in childn after tonsillectomy and/or adenoidectomy. Coadministration w/ MAO inhibitors or w/in 2 wk of its discontinuation.
Precautions
Hypothyroidism, adrenocortical insufficiency; prostatic hyperplasia, hypotension, shock, inflammatory or obstructive bowel disorders, myasthenia gravis. Patient who are ultra-rapid metabolisers of codeine. Renal and hepatic impairment. Pregnancy and lactation. Elderly or debilitated patients. May impair ability to drive or operate machinery. Monitoring Parameters Monitor BP, heart rate, respiratory and mental status.
Lactation: Excreted in breast milk; use with caution (AAP Committee states "compatible with nursing")
Pregnancy-Lactation
Pregnancy category: C; D if used for prolonged periods or near term
Interactions
Enhanced depressant effects w/ anaesthetics, anxiolytics, hypnotics, TCAs, antipsychotics. May alter effects of other compounds e.g. mexiletine, metoclopramide and domperidone.
Potentially Fatal: Additive effects w/ MAOI, avoid combination.
Adverse Effects
Side effects of Codeine :
>10%
Constipation,Drowsiness
1-10%
Hypotension,Tachycardia or bradycardia,Confusion,Dizziness,False feeling of well-being,Headache,Lightheadedness,Malaise,Paradoxical CNS stimulation,Restlessness,Rash, urticaria,Anorexia,Nausea, vomiting,Xerostomia,Ureteral spasm, urination decreased,LFTs increased,Burning at injection site,Weakness,Blurred vision,Dyspnea,Histamine release
<1%
Hypotension, with IV use,Anaphylactoid reaction (rare),Seizure, with excessive doses,Respiratory depression
Mechanism of Action
Codeine is a phenantrene-derivative opiate agonist which alters the perception of and response to pain by binding to opiate receptors in the CNS, blocking the ascending pain pathways. It also helps suppress cough by direct action in the medulla.
Note
Codophos 15mg Tablet manufactured by Vijayadeep Laboratories Pvt. Ltd.. Its generic name is Codeine. Codophos is availble in Nepal.
Farmaco Nepal drug index information on Codophos Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.