Cognitol Tablet
Vinpocetine
5mg
Sun Pharmaceutical Industries Ltd.
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Indications
Cognitol Tablet is used for:
Dementia, Cerebrovascular disorders, Stroke
Adult Dose
Oral
Adult
Tablet: 1-2 tablets thrice daily, the maintenance dose is 1 tablet thrice daily.
Parenteral
IM Injection: Daily dose of 20-40 mg are to be given until improvement of symptoms is reached (for not longer than 10 days) then oral treatment should be applied. If this regimen fails, infusion treatment should be started.
IV Infusion: The daily starting dose is 20 mg in slow drip infusion (2 ampoules in 500-1000 ml infusion solution). This dose can be increased to 1 mg/kg body weight
during 3 to 4 days. Treatment should be continued for 10-14 days depending on the tolerance of the patients and the dose should be gradually reduced before
discontinuation of treatment.
Child Dose
Renal Dose
Administration
Should be taken with food. Take after meals.
Contra Indications
Parenteral treatment- Severe ischaemic heart disease, severe rhythm disorders and pregnancy. Pregnancy, Lactation.
Precautions
Hypertension or cardiac dysfunction. In the acute stage until the improvement of symptoms parenteral treatment is recommended followed by oral treatment. In chronic cases oral therapy should be applied.
Pregnancy-Lactation
Interactions
Possible decrease in anticoagulation effect with warfarin.
Adverse Effects
Side effects of Vinpocetine :
Transient hypotension, tachycardia.
Mechanism of Action
Vinpocetine is derived from vincamine. It increases cerebral circulation and utilisation of oxygen and is used in a variety of cerebral disorders. Shown to inhibit cGMP phosphodiesterase that has may result in increased cerebral blood flow.
Reported to have calcium-channel blocker, voltage-gated sodium channel blocker, & acetylcholine release activities.
Note
Cognitol 5mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Vinpocetine. Cognitol is availble in Nepal.
Farmaco Nepal drug index information on Cognitol Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.