Cold Care Tablet
Chlorpheniramine + Acetaminophen (paracetamol) + Phenylephrine
1mg + 125mg + 2.5mg
National Healthcare Pvt. Ltd.
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Available as:
Indications
Cold Care Tablet is used for:
Relief of Cold & Fever
Adult Dose
Relief of Cold & Fever
Adults: 2 tablets PO q4hr; not to exceed 12 tablets/day
Child Dose
Relief of Cold & Fever
>12 years
Child: 2 tablets PO q4hr; not to exceed 12 tablets/day
Renal Dose
Administration
Contra Indications
Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency
Chlorpheniramine may cause significant confusional symptoms; not for administration to < 2 years of age
Use of MAO inhibitor within 14 days
Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Precautions
Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required
Caution in asthma, bladder neck obstruction, cardiovascular disease, COPD, GI obstruction, glaucoma, hepatic impairment, hyperthyroidism, increased intraocular pressure, malnutrition, renal impairment, elderly patients, patients taking CNS depressants or < 6 years of age with chlorpheniramine products
Caution in severe hypovolemia if taking acetaminophen products
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Chlorpheniramine + Acetaminophen (paracetamol) + Phenylephrine :
Hypotension,Hypertension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Euphoria,Excitability,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremors,Dermatologic rash,Anorexia,Agranulocytosis,Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia),Hemolytic anemia,Thrombocytopenia,Bilirubin and alkaline phosphatase may increase,Thickening of bronchial secretions,Wheezing
Mechanism of Action
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center.
Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.
Note
Cold Care 1mg + 125mg + 2.5mg Tablet manufactured by National Healthcare Pvt. Ltd.. Its generic name is Chlorpheniramine + Acetaminophen (paracetamol) + Phenylephrine. Cold Care is availble in Nepal.
Farmaco Nepal drug index information on Cold Care Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.