Cold Care Tablet

Chlorpheniramine + Acetaminophen (paracetamol) + Phenylephrine
1mg + 125mg + 2.5mg
National Healthcare Pvt. Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price

Indications

Cold Care Tablet is used for: Relief of Cold & Fever

Adult Dose

Relief of Cold & Fever Adults: 2 tablets PO q4hr; not to exceed 12 tablets/day

Child Dose

Relief of Cold & Fever >12 years Child: 2 tablets PO q4hr; not to exceed 12 tablets/day

Renal Dose

Administration

Contra Indications

Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency Chlorpheniramine may cause significant confusional symptoms; not for administration to < 2 years of age Use of MAO inhibitor within 14 days Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose

Precautions

Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required Caution in asthma, bladder neck obstruction, cardiovascular disease, COPD, GI obstruction, glaucoma, hepatic impairment, hyperthyroidism, increased intraocular pressure, malnutrition, renal impairment, elderly patients, patients taking CNS depressants or < 6 years of age with chlorpheniramine products Caution in severe hypovolemia if taking acetaminophen products

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Chlorpheniramine + Acetaminophen (paracetamol) + Phenylephrine : Hypotension,Hypertension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Euphoria,Excitability,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremors,Dermatologic rash,Anorexia,Agranulocytosis,Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia),Hemolytic anemia,Thrombocytopenia,Bilirubin and alkaline phosphatase may increase,Thickening of bronchial secretions,Wheezing

Mechanism of Action

Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center. Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.

Note

Cold Care 1mg + 125mg + 2.5mg Tablet manufactured by National Healthcare Pvt. Ltd.. Its generic name is Chlorpheniramine + Acetaminophen (paracetamol) + Phenylephrine. Cold Care is availble in Nepal. Farmaco Nepal drug index information on Cold Care Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Chlorpheniramine + Acetaminophen (paracetamol) + Phenylephrine :