Coldin P Syrup

Chlorpheniramine + Acetaminophen (paracetamol) + Pseudoepedrine
Deurali Janta Pharmaceuticals Pvt. Ltd.
Pack size 60ml
Dispensing mode
Source
Agent
Retail Price 75.00 NPR

Available as:

Indications

Coldin P Syrup is used for: Relief of Nasal Congestion, Cold & Fever

Adult Dose

Relief of Nasal Congestion, Cold & Fever Adults: Tablet: 2 tablets PO q4-6hr Syrup: 3 tsf 2-3 times daily

Child Dose

Relief of Nasal Congestion, Cold & Fever >12 years Child: Tablets: 2 tablets PO q4hr Syrup: 3 tsf 2-3 times daily

Renal Dose

Administration

Contra Indications

Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency Chlorpheniramine may cause significant confusional symptoms; not for administration to < 2 years of age Use of MAO inhibitor within 14 days Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose

Precautions

Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine Caution in asthma, bladder neck obstruction, cardiovascular disease, COPD, GI obstruction, glaucoma, hepatic impairment, hyperthyroidism, increased intraocular pressure, malnutrition, renal impairment, elderly patients, patients taking CNS depressants or < 6 years of age with chlorpheniramine products Caution in severe hypovolemia if taking acetaminophen products

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Chlorpheniramine + Acetaminophen (paracetamol) + Pseudoepedrine : Hypotension,Hypertension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Euphoria,Excitability,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremors,Dermatologic rash,Anorexia,Agranulocytosis,Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia),Hemolytic anemia,Thrombocytopenia,Bilirubin and alkaline phosphatase may increase,Thickening of bronchial secretions,Wheezing

Mechanism of Action

Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center. Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.

Note

Coldin P Syrup manufactured by Deurali Janta Pharmaceuticals Pvt. Ltd.. Its generic name is Chlorpheniramine + Acetaminophen (paracetamol) + Pseudoepedrine. Coldin P is availble in Nepal. Farmaco Nepal drug index information on Coldin P Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Chlorpheniramine + Acetaminophen (paracetamol) + Pseudoepedrine :