Combigan Eye Drop
Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep
Allergan India Pvt. Ltd.
| Pack size | 5ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 616.83 NPR |
Available as:
Indications
Combigan Eye Drop is used for:
Open-angle glaucoma, Ocular hypertension
Adult Dose
Adult: Ophth: Instill 1 drop 2 times/day approximately 12 hours apart.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity. Patients receiving MAO inhibitor therapy.
Precautions
Patients wearing soft contact lenses should wait for at least 15 min after instilling brimonidine tartrate before inserting soft contact lenses. Renal or hepatic impairment. CV disease. Use with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangitis obliterans. Pregnancy, lactation.
Lactation: use caution
Pregnancy-Lactation
Interactions
Brimonidine Tartrate: Possibility of an additive or potentiating effect with CNS depressants e.g. alcohol, barbiturates, opiates, sedatives or anaesthetics. Caution when used with ?-blockers (ophthalmic and systemic), antihypertensives or cardiac glycosides. TCAs can affect the metabolism and uptake of circulating amines.
Timolol: Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive effects w/ other antihypertensives (e.g. hydralazine, methyldopa). Increased ?-adrenergic blockade (e.g. decreased heart rate) w/ quinidine. Rebound HTN due to abrupt withdrawal of clonidine. Hypotensive effect may be antagonised by NSAIDs (e.g. indomethacin, ibuprofen).
Adverse Effects
Side effects of Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep :
5-15%
Allergic conjunctivitis,Conjunctival folliculosis,Conjunctival hyperemia,Eye pruritus,Ocular burning,Stinging
1-5%
Asthenia,Blepharitis,Corneal erosion,Depression,Epiphora,Eye discharge,Eye dryness,Eye irritation,Eye pain,Eyelid edema,Eyelid erythema,Eyelid pruritus,Foreign body sensation,Headache,Hypertension,Oral dryness,Somnolence,Superficial punctate keratitis,Visual disturbance
Mechanism of Action
Brimonidine is an alpha 2-adrenoceptor agonist which works to reduce aqueous humor production and increase uveoscleral flow.
Timolol is a non-selective beta-adrenergic receptor blocker. It does not have significant intrinsic sympathomimetic activity, direct myocardial depressant activity or local anaesth activity. Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humour formation. beta-blockade also causes lowering of BP.
Note
Combigan Eye Drop manufactured by Allergan India Pvt. Ltd.. Its generic name is Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep. Combigan is availble in Nepal.
Farmaco Nepal drug index information on Combigan Eye Drop is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.