Copar Tablet
Metoclopramide + Paracetamol
5mg + 500mg
Comed Chemicals Ltd
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Indications
Copar Tablet is used for:
Migraine
Adult Dose
Oral
Migraine
Adult: Each tablet containing paracetamol 500 mg and metoclopramide 5 mg:
>20 yr: Initially, 2 tablets at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 6 tablets/24 hr.
15-20 yr and ?60 kg: Initially, 2 tablets at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 5 tablets/24 hr.
15-20 yr and 30-59 kg or 12-14 yr and >30 kg: Initially, 1 tablet at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 3 tablets/24 hr.
Child Dose
Renal Dose
Administration
Contra Indications
Lactation. Children <12 yr.
Precautions
Porphyria, epilepsy, parkinsonism, history of depression, pregnancy. Renal or hepatic impairment. May impair ability to drive or operate machinery. Risk of acute hypersensitivity reactions in patients with phaeochromocytoma. Exclude the possibility of an underlying disorder if patient has persistent vomiting.
Pregnancy-Lactation
Interactions
Action of metoclopramide may be antagonised by anticholinergics and opioid analgesics. Metoclopramide may affect the absorption of orally administered drugs when given together.
Adverse Effects
Side effects of Metoclopramide + Paracetamol :
Nausea, allergic reactions, skin rashes, acute renal tubular necrosis. Constipation or diarrhoea; drowsiness, headache, depression, lassitude, extrapyramidal reactions (especially if combined with phenothiazines); galactorrhoea; parkinsonism; neuroleptic malignant syndrome; tardive dyskinesia.
Potentially Fatal: Paracetamol: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage. Metoclopramide: Very rarely, hypertensive crisis in patients with pheochromocytoma. Cardiac conduction disorders (IV admin).
Mechanism of Action
Metoclopramide is a dopamine antagonist, which binds to D2 receptors in the central and peripheral nervous system. It has anticholinesterase and antiemetic effects. Paracetamol is a centrally and peripherally acting non-opioid analgesic and antipyretic.
Note
Copar 5mg + 500mg Tablet manufactured by Comed Chemicals Ltd. Its generic name is Metoclopramide + Paracetamol. Copar is availble in Nepal.
Farmaco Nepal drug index information on Copar Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.