Corex dx Syrup

Dextromethorphan + Chlorpheniramine
4 mg/5ml,10 mg/5ml
Pfizer Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 51.46 NPR

Available as:

Indications

Corex dx Syrup is used for: Cough & Cold

Adult Dose

Oral Cough & Cold Syrup: Chlorpheniramine/Dextromethorphan (2mg/15mg) Adult: 2 tsf 6 hourly

Child Dose

Oral Cough & Cold Syrup: Chlorpheniramine/Dextromethorphan (2mg/15mg) Child >12 yrs: 2 tsf 6 hourly Child: < 12years: 1 tsf 6 hourly Child <6 years Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Hypersensitivity Within 2 wk of taking a monoamine oxidase (MAO) inhibitor Sedation of children

Precautions

Caution in children younger than 6 years Benign prostatic hypertrophy Glaucoma Caution in productive cough (do not suppress expectoration of phlegm) Chronic respiratory conditions (eg, asthma, COPD) Alcohol consumption or other CNS depressants may increase risk for drowsiness May impair ability to safely drive vehicle or operate machinery Lactation: Unknown whether distributed in breast milk, caution advised

Pregnancy-Lactation

Interactions

May cause hypertensive crisis w/ MAOIs.

Adverse Effects

Side effects of Dextromethorphan + Chlorpheniramine : Sedation ranging from mild drowsiness to deep sleep,CNS depression,Excitability may occur in children,Dizziness,Impaired coordination,Muscular weakness,Anorexia,Nausea,Vomiting,Urinary retention,Blurred vision,Xerostomia,Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitations, seizures reported infrequently

Mechanism of Action

Chlorpheniramine: Histamine H1-receptor antagonist; sedative effect is low; antihistamine and anticholinergic activity is moderate Dextromethorphan: Antitussive; derivative of levorphanol; acts on cough center in medulla

Note

Corex dx 4 mg/5ml,10 mg/5ml Syrup manufactured by Pfizer Ltd.. Its generic name is Dextromethorphan + Chlorpheniramine. Corex dx is availble in Nepal. Farmaco Nepal drug index information on Corex dx Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Dextromethorphan + Chlorpheniramine :