Cosome Expectorant Oral Solution

Chlorpheniramine + Phenylephrine + Bromhexine
Merck Ltd.
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Indications

Cosome Expectorant Oral Solution is used for: Nasal Congestion, Sneezing, Cough, Common Cold, Hay Fever, Allergic Rhinitis

Adult Dose

Nasal Congestion, Sneezing, Cough, Common Cold, Hay Fever, Allergic Rhinitis 1 tablet PO q8hr

Child Dose

Nasal Congestion, Sneezing, Cough, Common Cold, Hay Fever, Allergic Rhinitis >12 Years Old 1 tablet PO q8hr

Renal Dose

Administration

Contra Indications

Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer

Precautions

Patient w/ history of peptic ulceration, asthma. Severe hepatic or renal impairment. Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates Lactation: excretion in milk unknown/contraindicated

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Chlorpheniramine + Phenylephrine + Bromhexine : Angioedema, rash, urticaria, pruritus, bronchospasm, nausea, vomiting, dizziness, sweating, headache, diarrhoea, upper abdominal pain, transient increase in serum aminotransferase values. Hypertension,Hypotension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Excitability,Euphoria,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremor,Anorexia,Agranulocytosis,Hemolytic anemia,Thrombocytopenia,Thickening of bronchial secretions,Wheezing

Mechanism of Action

Bromhexine enhances mucus transport by reducing mucus viscosity and by activating the ciliated epithelium (mucociliary clearance). Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.

Note

Cosome Expectorant Oral Solution manufactured by Merck Ltd.. Its generic name is Chlorpheniramine + Phenylephrine + Bromhexine. Cosome Expectorant is availble in Nepal. Farmaco Nepal drug index information on Cosome Expectorant Oral Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Chlorpheniramine + Phenylephrine + Bromhexine :