D Phenicol 250 Capsule
Chloramphenicol
250mg
G.D. Laboratories Pvt. Ltd.
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Available as:
Indications
D Phenicol 250 Capsule is used for:
Tetracycline-resistant cholera, typhoid, brain abscesses, meningitis, Granuloma inguinale, Anthrax, Listeriosis, Gas gangrene, Whipple's disease, gastroenteritis, melioidosis, Plague, Psittacosis, Q fever, Tularaemia
Adult Dose
Adult:
Serious Infections Caused by Susceptible Strains
PO/IV 50 mg/kg/day in 4 divided doses, may increase to 100 mg/kg/day in more severe infections.
Hepatic impairment: Dose reduction may be required.
Child Dose
PO/IV Susceptible infections
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses.
Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses.
Children: 50-75 mg/kg/day in 4 divided doses increased to 75-100 mg/kg/day for meningitis or severe infections.
Renal Dose
Renal impairment: Dose reduction may be required.
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contra Indications
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.
Precautions
Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.
Lactation: enters breast milk; discontinue drug or do not nurse
Pregnancy-Lactation
Interactions
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.
Adverse Effects
Side effects of Chloramphenicol :
<1%
Nightmares,Headache,Rash,Diarrhea,Stomatitis,Enterocolitis,Nausea,Vomiting,Bone marrow suppression,Aplastic anemia,Peripheral neuropathy,Optic neuritis,Gray syndrome
Potentially Fatal: Bone marrow suppression and irreversible aplastic anaemia. Neutropenia, thrombocytopenia. Grey baby syndrome. Rarely, anaphylaxis.
Mechanism of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Note
D Phenicol 250 250mg Capsule manufactured by G.D. Laboratories Pvt. Ltd.. Its generic name is Chloramphenicol. D Phenicol 250 is availble in Nepal.
Farmaco Nepal drug index information on D Phenicol 250 Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.