Dacmed Injection
Dacarbazine
200mg
United Biotech
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| Retail Price | 714.17 NPR |
Indications
Dacmed Injection is used for:
Metastatic melanoma, Hodgkin's disease , Soft tissue sarcoma
Adult Dose
Intravenous
Metastatic melanoma
Adult: 2-4.5 mg/kg daily for 10 days, repeat at 4-wk intervals or 200-250 mg/m2 BSA daily for 5 days, repeat at 3-wk intervals or 850 mg/m2 BSA by infusion, repeat at 3-wk intervals.
Hodgkin's disease
Adult: 150 mg/m2 BSA daily for 5 days, repeat every 4 wk or 375 mg/m2 BSA every 15 days in combination with other agents.
Soft tissue sarcoma
Adult: 250 mg/m2 BSA daily for 5 days repeated every 3 wk. Usually given with doxorubicin.
Child Dose
Hodgkin's Disease
With other antineoplastics, eg ABVD
Dosage dependent on protocol150 mg/m² IV qDay for 5 days, repeat q4Weeks OR
375 mg/m² IV on Day 1; repeat every 15 Days
Renal Dose
Administration
IV Preparation
Reconstitute with a 9.9 mL (100 mg vial) or 19.7 mL (200 mg vial) of SWI to obtain a 10 mg/mL soln
For infusion, dilute with D5W or NS up to 250 mL
IV Administration
IVP over 1 min (may be irritant & painful) OR infusion over 15-60 min
Contra Indications
Bone marrow suppression; hypersensitivity.
Precautions
Hepatic or renal impairment. Pregnancy, lactation.
Lactation: not known if excreted in breast milk, do not nurse
Pregnancy-Lactation
Interactions
Impairs immune response to vaccines; possible infection after admin of live vaccines. Effect increased by CYP1A2 inhibitors e.g. amiodarone, ciprofloxacin, fluvoxamine, ketoconazole, lomefloxacin, ofloxacin and rofecoxib. Effect decreased by CYP1A2 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital and rifampicin.
Adverse Effects
Side effects of Dacarbazine :
>10%
Nausea (>90%),Vomiting(>90%),Injection site pain,Leukopenia,Thrombocytopenia
1-10%
Alopecia,Rash,Photosensitivity,Anorexia,Metallic taste,Flu-like syndrome
Frequency Not Defined
Anaphylaxis,Photosensitivity (rare),Cerebral hemorrhage,Seizure,Myelosuppression,Hepatic necrosis,Hepatic vein thrombosis,Hepatotoxicity
Potentially Fatal: Myelosuppression; hepatotoxicity, anaphylaxis.
Mechanism of Action
The exact mechanism of action is still unclear but it appears to form methylcarbonium ions that attack nucleophilic groups by attaching to the 7-position of guanine on DNA. It also cross-links DNA strands leading to inhibition of DNA, RNA and protein synthesis.
Note
Dacmed 200mg Injection manufactured by United Biotech. Its generic name is Dacarbazine. Dacmed is availble in Nepal.
Farmaco Nepal drug index information on Dacmed Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.