Dafexin D Syrup
Cephalexin
125mg
Saga Laboratories
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Indications
Dafexin D Syrup is used for:
Pneumonia, Otitis media, Bacterial endocarditis, Streptococcal pharyngitis, Cellulitis, Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Genitourinary tract infections, Acute prostatitis
Adult Dose
Oral
Bone and joint infections; Respiratory tract infections, Genitourinary Tract Infections, Otitis Media
Adults
1 to 4 g/day in divided doses.
Usual dose is 250 mg every 6 hours.
Streptococcal pharyngitis, skin and skin structure infections, uncomplicated cystitis, cellulitis and mastitis
>15 years 500 mg every 12 hours.
Child Dose
Children
25 to 50 mg/kg/day q12h
For streptococcal pharyngitis in patients >1year old and for skin and skin structure infections, divide total daily dose and give every 12 hours.
In sever infections, 75–100 mg/kg/day for bone and joint, otitis media or severe infections q6–8h
Beta-hemolytic streptococcal infections: Continue treatment for at least 10 days.
Renal Dose
Renal impairment:
CrCl (ml/min)
40-50 Max: 3 g daily.
10-40 Max: 1.5 g daily.
<10 Max: 750 mg daily.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
Hypersensitivity to penicillins; pseudomembranous colitis; renal failure; pregnancy and lactation.
Lactation: Drug excreted in breast milk; use with caution
Pregnancy-Lactation
Interactions
Concurrent use w/ metfromin may result to fatal lactic acidosis. May enhance the anticoagulant effect of vit K antagonists (e.g. warfarin). Increased risk of nephrotoxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide) and other potentially nephrotoxic antibiotics (e.g. aminoglycosides, polymyxin, colistin). Prothrombin time may be prolonged when used concomitantly w/ oral anticoagulants. May reduce the effects of OCs. Hypokalaemia may result from concomitant use of cefalexin and cytotoxic drugs for leukaemia. Uricosuric drugs (e.g. probenecid) may suppress renal excretion, resulting to increased plasma levels of cefalexin. May diminish the therapeutic effect of Na picosulfate, BCG and typhoid vaccine. May reduce serum level w/ multivitamins/minerals.
Adverse Effects
Side effects of Cephalexin :
GI disturbances (e.g. nausea, vomiting, diarrhoea, abdominal discomfort), dyspepsia; allergic reactions (e.g. rash urticaria, angioedema); genital and anal pruritus, genital candidiasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis and joint disorders; eosinophilia, neutropenia, thrombocytopenia, haemolytic anaemia, slightly elevated AST and ALT. Rarely, erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis; cholestatic jaundice, transient hepatitis.
Potentially Fatal: Anaphylactic reactions; nephrotoxicity.
Mechanism of Action
Cefalexin binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Dafexin 125mg D Syrup manufactured by Saga Laboratories. Its generic name is Cephalexin. Dafexin is availble in Nepal.
Farmaco Nepal drug index information on Dafexin D Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.