Dapsone 50 Tablet
Dapsone
50mg
Glaxo SmithKline Pharmaceuticals Ltd.
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Available as:
Indications
Dapsone 50 Tablet is used for:
Pneumonia, Acne, Leprosy, Dermatitis herpetiformis
Adult Dose
Dermatitis Herpetiformis
50 mg PO qDay, titrate to 300 mg qDay or higher to achieve desired effect
Reduce dose to minimum effective dose within the range of 50-300 mg qDay as soon as possible
Leprosy
100 mg PO qDay, in combination with other antileprosy drugs
Tuberculoid or Lepromatous Disease
100 mg PO qDay with rifampin 600 mg PO qDay
Child Dose
Child: PO 2 mg/kg, max 100 mg q24h
4 mg/kg, max 200 mg Once weekly
Renal Dose
Administration
Contra Indications
Hypersensitivity. Severe anaemia, porphyria.
Precautions
G6PD deficiency, methaemoglobin or Hb M. Perform regular blood counts and monitor liver function regularly. Pregnancy and lactation.
Lactation: Enters breast milk; not recommended (AAP Committee states "compatible with nursing")
Pregnancy-Lactation
Interactions
Decreased serum conc of dapsone when used with rifampicin. Increased plasma conc with probenecid, trimethoprim. Antagonize clofazimine.
Adverse Effects
Side effects of Dapsone :
1-10%
Hemolysis,Methemoglobinemia
<1%
Reactional states (ie, abrupt changes in clinical activity occurring during any leprosy treatment; classified as reversal of erythema nodosum leprosum reactions),Insomnia,Headache,Exfoliative dermatitis,Photosensitivity,Nausea,Vomiting,Anemia,Leukopenia,Agranulocytosis,Hepatitis,Cholestatic jaundice,Peripheral neuropathy (usually in nonleprosy patients),Blurred vision,Tinnitus,SLE
Potentially Fatal: Agranulocytosis, serious cutaneous hypersensitivity reactions, exfoliative dermatitis.
Mechanism of Action
Dapsone inhibits folic acid synthesis by preventing normal bacterial utilization of PABA (PABA).
Note
Dapsone 50 50mg Tablet manufactured by Glaxo SmithKline Pharmaceuticals Ltd.. Its generic name is Dapsone. Dapsone 50 is availble in Nepal.
Farmaco Nepal drug index information on Dapsone 50 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.