Depnon Tablet
Mianserin
10mg
Organon (India) Ltd
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| Retail Price | 8.06 NPR |
Indications
Depnon Tablet is used for:
Depression
Adult Dose
Oral
Depression
Adult: Initially, 30-40 mg daily gradually increased if necessary. Maintenance: 30-90 mg daily as a single dose at night or in divided doses. Max: 200 mg/day.
Elderly: Initially, 30 mg slowly increased if necessary.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
lactation, porphyria.
Precautions
Concurrent CNS depression; epilepsy; MAOIs withdrawal (at least 14 days after discontinuation); hepatic, renal or cardiac insufficiency; heart block or recent MI; angle-closure glaucoma; prostatic hyperplasia; diabetes mellitus; monitor blood count regularly.
Pregnancy-Lactation
Interactions
Blood levels decreased by phenobarbitone, carbamazepine and phenytoin. Monitor blood pressure with antihypertensive therapy. Mianserin may antagonise the action of antiepileptics by lowering the convulsive threshold. CNS depressant effects enhance by alcohol, sedatives.
Potentially Fatal: Avoid MAOIs (and for 14 days after discontinuation).
Adverse Effects
Side effects of Mianserin :
Drowsiness; liver dysfunction and jaundice; gynaecomastia; convulsions; hypomania; hypotension; hypertension; coma; arthralgia; oedema; tachycardia; bradycardia; vomiting; dizziness and ataxia; anticholinergic effects.
Potentially Fatal: Bone marrow suppression.
Mechanism of Action
Mianserin is a structural analogue of serotonin (5-HT) with antagonistic effects at 5-HT2A, 5-HT2C and 5-HT3 receptors. Mianserin also blocks the inhibitory alpha2-receptors, thus leading to an increase in noradrenaline release.
Note
Depnon 10mg Tablet manufactured by Organon (India) Ltd. Its generic name is Mianserin. Depnon is availble in Nepal.
Farmaco Nepal drug index information on Depnon Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.