Detuss Syrup

Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride
Lomus Pharmaceutical Pvt. Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 100.00 NPR

Indications

Detuss Syrup is used for: Flu, Colds, Runny nose, Dry coughs, Non-productive cough, Nasal congestion

Adult Dose

Oral Cough and common cold Adult: 2 teaspoonful three times a day.

Child Dose

Children Over 12 years 2 teaspoonful three times a day 6-12 years 1 teaspoonful three times a day 2-6 years 1/2 teaspoonful three times a day or as directed by the physician

Renal Dose

Administration

Contra Indications

Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough.

Precautions

3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.

Pregnancy-Lactation

Interactions

Dextromethorphan: Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol. Potentially Fatal: Memantine, moclobemide. Triprolidine + Pseudoephedrine: Increased BP with other sympathomimetic agents (e.g. decongestants, TCA, appetite suppressants). Reduced hypotensive effects of methyldopa, ?- and ?-adrenergic blockers. Increased side effects (e.g. somnolence, agitation) with atomoxetine. Potentially Fatal: Increased risk of hypertensive crisis with furazolidine, avoid concurrent use. Increased risk of hypertensive crisis with MAOIs; avoid concurrent use or within 2 wk after stopping MAOIs. Increased risk of psychosis with bromocriptine.

Adverse Effects

Side effects of Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride : Dizziness, GI disturbances.

Mechanism of Action

Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine, an alpha- and beta-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.

Note

Detuss Syrup manufactured by Lomus Pharmaceutical Pvt. Ltd.. Its generic name is Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride. Detuss is availble in Nepal. Farmaco Nepal drug index information on Detuss Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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