DIANA Cream

Tretinoin Topical
0.05%W/W
Panas Pharmaceutical Pvt. Ltd.
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Indications

DIANA Cream is used for: Acne, Mottled hyperpigmentation, Roughness and fine wrinkling of photodamaged skin

Adult Dose

Topical/Cutaneous Acne vulgaris Adult: Apply once, usually at bedtime, onto affected area which has been previously cleansed to remove excessive oiliness and dried. Therapeutic response may be seen after 6-8 wk. Mottled hyperpigmentation, roughness and fine wrinkling of photodamaged skin Adult: Apply a pea-sized amount onto entire face once daily at night. Therapeutic response may be seen after 6 mth.

Child Dose

Topical/Cutaneous Acne Vulgaris <12 years: Safety and efficacy not established >12 years: Apply once, usually at bedtime, onto affected area

Renal Dose

Administration

Contra Indications

Hypersensitivity to retinoids. Application to eczematous, sunburnt or abraded skin. Pregnancy, lactation.

Precautions

Avoid concomitant topical applications, esp keratolytic agents. Avoid exposure to sunlight, UV light and weather extremes (e.g. cold). Keep away from eyes, mouth, angles of nose, mucous membranes or open wounds. In case of severe local erythema, oedema, blistering or crusting, use less frequently or discontinue. Avoid medicated or drying soaps, abrasive soaps and cleansers, frequent washing and harsh scrubbing. Avoid use of topical preparations with high concentrations of alcohol, menthol, spices or lime.

Pregnancy-Lactation

Interactions

Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides. Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.

Adverse Effects

Side effects of Tretinoin Topical : Initial exacerbation of symptoms, skin irritation, stinging on application, oedema, blistering, crusting of the skin, erythema, scaling, photosensitivity, temporary hypo/hyperpigmentation.

Mechanism of Action

Tretinoin is a trans-retinoic acid form of vitimin A. It stimulates mitosis and turnover of follicular epithelial cells and reduce their cohesiveness. This facilitates extrusion of existing comedones and prevents formation of new comedone. It also exhibits thinning effect on the stratum corneum. In acute promyelocytic leukaemia, it induces cellular differentiation and decreases proliferations.

Note

DIANA 0.05%W/W Cream manufactured by Panas Pharmaceutical Pvt. Ltd.. Its generic name is Tretinoin Topical. DIANA is availble in Nepal. Farmaco Nepal drug index information on DIANA Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Tretinoin Topical :