Diastazole Forte Syrup
Metronidazole + Diloxanide Furoate
200mg + 250mg/5ml
Siddhartha Pharmaceuticals Pvt. Ltd.
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Available as:
Indications
Diastazole Forte Syrup is used for:
Treatment of amoebiasis and other protozoal disease.
Adult Dose
Oral
1 (400/500mg) Tablet 3 times daily for 7-10 days.
Susp: (200/250 mg/5ml): 2 tsf 3 times daily.
Child Dose
Oral
Child
Susp: (200/250 mg/5ml): 1-2 tsf 3 times daily.
Renal Dose
Administration
Contra Indications
Hypersensitivity, blood dyscrasias, active CNS disease, serious neurological disease, seizures, severe hepatic failure, 1st trimester pregnancy, lactation.
Precautions
Severe Renal & Hepatic impairment. Caution should be exercised in pregnant and breastfeeding women.
Pregnancy-Lactation
Interactions
Acute psychoses with disulfiram. Additive or synergistic effect with other antimicrobials. Disulfiram like reaction with alcohol. Enhances action of coumarin anticoagulants. Blood levels increased by cimetidine. Effect reduced by phenobarbitone.
Adverse Effects
Side effects of Metronidazole + Diloxanide Furoate :
Seizures, headache, dizziness, peripheral neuropathies, unpleasant metallic taste, furred tongue, glossitis, pseudomembranous colitis, GI disturbances, rash, urticaria, pruritus, paraesthesias, superinfection; transient leucopaenia, thrombocytopenia. Raised liver enzyme values, cholestatic hepatitis, jaundice.
Mechanism of Action
Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.
Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.
Note
Diastazole Forte 200mg + 250mg/5ml Syrup manufactured by Siddhartha Pharmaceuticals Pvt. Ltd.. Its generic name is Metronidazole + Diloxanide Furoate. Diastazole Forte is availble in Nepal.
Farmaco Nepal drug index information on Diastazole Forte Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Some other brands of Metronidazole + Diloxanide Furoate :
Tablet
Diarstat forte
400mg + 500mg
Nepal Pharmaceuticals Pvt. Ltd.
Tablet
Protogyl DF
400mg + 500mg
Deurali Janta Pharmaceuticals Pvt. Ltd.
Suspention
Protogyl DF
100mg + 125mg/5ml
Deurali Janta Pharmaceuticals Pvt. Ltd.
Suspention
Diarstat
Nepal Pharmaceuticals Pvt. Ltd.
Tablet
Amet DF forte
400mg + 500mg
Apex Pharmaceuticals Pvt. Ltd.