Digene Tablet
Magnesium Hydroxide + Simethicon + Magnesium Aluminium Silicate + Aluminium Hydroxide
Abbott India Ltd.
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| Retail Price | 1.60 NPR |
Indications
Digene Tablet is used for:
Dyspepsia, Abdominal Bloating, Flatulence
Adult Dose
Adult:
Tablet:
Dyspepsia, Abdominal Bloating
PO Antacid Up to 1 g/day.
Hyperphosphataemia in chronic renal failure Up to 10 g/day in divided doses w/ meals.
Child Dose
Renal Dose
Administration
Should be taken on an empty stomach.
Contra Indications
Hypersensitivity to aluminium salts.
Precautions
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Lactation: excretion in milk unknown
Pregnancy-Lactation
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Simethicon: None well documented.
Adverse Effects
Side effects of Magnesium Hydroxide + Simethicon + Magnesium Aluminium Silicate + Aluminium Hydroxide :
Aluminum hydroxide
Chalky taste,Constipation,Fecal impaction,Stomach cramps,Nausea,Vomiting,Rebound hyperacidity,Aluminum intoxication,Hypophosphatemia,Milk-alkali syndrome,Osteomalacia
Magnesium hydroxide
Diarrhea,Hypermagnesemia
Simethicone
Loose stools
Mechanism of Action
Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH.
Magnesium hydroxide: Promotes bowel evacuation by causing osmotic retention of fluid, which causes the colon to distend with increased peristaltic activity; forms magnesium chloride when reacts with hydrochloric acid.
Simethicone: Disperses and prevents gas pockets in the GI system by decreasing surface tension of gas bubles.
Note
Digene Tablet manufactured by Abbott India Ltd.. Its generic name is Magnesium Hydroxide + Simethicon + Magnesium Aluminium Silicate + Aluminium Hydroxide. Digene is availble in Nepal.
Farmaco Nepal drug index information on Digene Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.