Dinir Tablet
Cefdinir
125mg
Time Pharmaceuticals Pvt. Ltd.
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| Retail Price | 18.00 NPR |
Available as:
Indications
Dinir Tablet is used for:
Community-acquired pneumonia, Susceptible infections, Sinusitis, Otitis media, Sore throat, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Acute Maxillary Sinusitis
Adult Dose
Community-Acquired Pneumonia, Skin/Skin Structure Infections
300 mg PO q12hr for 10 days
Respiratory Tract Infections, Acute Maxillary Sinusitis
300 mg PO q12hr or 600 mg PO q24hr for 10 days
Hepatic impairment
No dosage adjustment necessary
Child Dose
<6 months: Safety and efficacy not established
6 months-12 years: 7 mg/kg PO q12hr for 5-10 days or 14 mg/kg PO q24hr for 10 days
>12 years or >43 kg: 300 mg PO q12hr or 600 mg PO q24hr for 10 days
Renal Dose
Renal impairment:
CrCl (ml/min)
<30 300 mg once daily.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity.
Precautions
Penicillin-sensitive patients; superinfection; seizure; pseudomembranous colitis; pregnancy, lactation; renal or hepatic insufficiency.
Lactation: Unknown whether drug is excreted in milk
Pregnancy-Lactation
Interactions
Concomitant admin w/ antacids or Fe supplements reduce the rate and extent of absorption. Admin w/ Fe supplements may cause reddish stools. Decreased renal elimination w/ probenecid.
Adverse Effects
Side effects of Cefdinir :
>10%
Diarrhea (8-15%)
1-10%
Vaginal moniliasis (<4%),Nausea (3%),Rash (3%),Headache (2%),Increased urine leukocytes (2%),Increased urine protein (1-2%),Decreased lymphocytes (1%),Glycosuria (1%),Increased alkaline phosphatase (1%),Increased eosinophils (1%),Increased platelets (1%)
Potentially Fatal: Anaphylaxis; renal and hepatic failure.
Mechanism of Action
Cefdinir binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Dinir 125mg Tablet manufactured by Time Pharmaceuticals Pvt. Ltd.. Its generic name is Cefdinir. Dinir is availble in Nepal.
Farmaco Nepal drug index information on Dinir Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.