Dizone Tablet
Disulfiram
250mg
Ozone Pharmaceuticals Ltd.
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| Retail Price | 3.68 NPR |
Indications
Dizone Tablet is used for:
Alcoholism
Adult Dose
Alcoholism
Only administer after the patient has abstained from ethanol for at least 12 hr
Use ONLY as adjunct to supportive & psychotherapeutic treatment; in motivated patient
500 mg PO qDay initially for 1-2 weeks; not to exceed 500 mg/day
Maintenance: 250 mg PO qDay (125-500 mg range); continue therapy until a bases for self-control has been established; patient may continue to take drug therapy for months or even years
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Contra Indications
Cardiac failure, coronary artery disease, history of CVA, HTN, psychosis or severe personality disorders. Patients receiving metronidazole, paraldehyde, alcohol or alcohol-containing preparations (e.g. cough syrups, tonics), alcohol-based topical preparations.
Precautions
Use caution in diabetes, hypothyroidism, seizures, nephritis, hepatic impairment. Severe hepatitis and/or hepatic failure has been associated with therapy even in patients without prior history of abnormal hepatic function. Patient Counselling Do not take alcohol (including alcohol-containing preparations) for up to 14 days after discontinuation. This drug may cause drowsiness or fatigue, if affected, do not drive or operate machinery. Monitoring Parameters Monitor LFTs (baseline and follow-up every 10-14 days), CBC and serum chemistries.
Lactation: excretion in milk unknown/not recommended
Pregnancy-Lactation
Interactions
Enhances the effects of phenytoin, theophylline and coumarin anticoagulants. Inhibits the metabolism and excretion of rifampicin. Inhibits the metabolism of certain benzodiazepines (e.g. chlordiazepoxide, diazepam). Increased incidence of confusion and behavioural changes w/ isoniazid. May potentiate organic brain syndrome and choreoatphetosis w/ pimozide. Amitryptyline and chlorpromazine may increase the intensity of disulfiram-alcohol reaction.
Potentially Fatal: Disulfiram blocks the metabolism of alcohol leading to disulfiram-alcohol reaction. Increased toxic reactions w/ metronidazole. May increase serum concentration of paraldehyde.
Adverse Effects
Side effects of Disulfiram :
Drowsiness, fatigue, garlic-like or metallic aftertaste, GI upsets, body odour, halitosis, headache, impotence, acneiform or allergic dermatitis, peripheral and optic neuropathies, psychotic reactions. Disulfiram-alcohol reaction (manifested by flushing of the face, throbbing in the head and neck, pulsating headache, resp difficulties, nausea, copius vomiting, sweating, thirst, chest pain, tachycardia, palpitations, marked hypotension, giddiness, weakness, blurred vision, confusion, and in severe cases, resp depression, CV collapse, cardiac arrhythmias, MI, acute heart failure, unconsciousness, convulsions, and sudden death). Rarely, blood dyscrasias.
Potentially Fatal: Severe hepatitis and/or hepatic failure.
Mechanism of Action
Disulfiram inhibits aldehyde dehydrogenase, the oxidative enzyme of acetaldehyde, a metabolite of alcohol. The latter is accumulated in the blood, thus producing unpleasant symptoms of disulfiram-alcohol reaction when a patient has taken small amounts of alcohol.
Note
Dizone 250mg Tablet manufactured by Ozone Pharmaceuticals Ltd.. Its generic name is Disulfiram. Dizone is availble in Nepal.
Farmaco Nepal drug index information on Dizone Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.