Domfast DT Tablet
Domperidone
5mg
Universal Formulation
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| Retail Price | 3.00 NPR |
Available as:
Indications
Domfast DT Tablet is used for:
Gastritis, Lactation, Migraine, Nausea and vomiting, Gastroparesis, Non ulcer dyspepsia
Adult Dose
Oral
Adults:
Nausea and vomiting 10-20 mg 4-8 hrly. Max: 80 mg/day.
Non ulcer dyspepsia 10 mg 3-4 times daily. Max: 20 mg 3-4 times daily. Last dose to be taken at bedtime.
Migraine 20 mg 4 hrly. Max: 4 doses/24 hr.
Rectal:
Nausea and vomiting 60 mg twice daily.
Elderly: No dosage adjustment needed.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Oral
Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Rectal
Child: <12 yr >15 kg: 30 mg bid;
>12 yr >35 kg: 60 mg bid.
Renal Dose
Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Reduce dosing to 1-2 times daily w/ prolonged treatment.
Administration
Should be taken on an empty stomach. Take 15-30 min before meals.
Contra Indications
Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone, chronic admin or routine prophylaxis of postoperative nausea and vomiting.
Precautions
Phaeochromocytoma; children<2 yr, elderly; renal or hepatic impairment. Risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
May antagonise the hypoprolactinaemic effect of bromocriptine. May antagonise the prokinetic effect w/ opioid analgesics and antimuscarinics.
Potentially Fatal: Potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin or ritonavir) may increase serum domperidone levels and subsequently increasing the risk of QT prolongation.
Adverse Effects
Side effects of Domperidone :
Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, skin rash, itch.
Potentially Fatal: Convulsions, arrhythmias and cardiac arrest, dysrrhythmias in patients with CV disease or hypokalaemia, patients on cancer chemotherapy. Seizures; hypertensive crisis in patients with phaeochromocytoma.
Mechanism of Action
Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.
Note
Domfast 5mg DT Tablet manufactured by Universal Formulation. Its generic name is Domperidone. Domfast is availble in Nepal.
Farmaco Nepal drug index information on Domfast DT Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.