Dopatec Injection
Dopamine Hydrochloride
40mg/5ml
National Healthcare Pvt. Ltd.
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Indications
Dopatec Injection is used for:
Shock, Acute heart failure, Hypotension
Adult Dose
Hemodynamic Conditions
Treatment of hypotension, low cardiac output, poor perfusion of vital organs; used to increase mean arterial pressure in septic shock patients who remain hypotensive after adequate volume expansion
1-5 mcg/kg/min IV (low dose): May increase urine output and renal blood flow
5-15 mcg/kg/min IV (medium dose): May increase renal blood flow, cardiac output, heart rate, and cardiac contractitlity
20-50 mcg/kg/min IV (high dose): May increase blood pressure and stimulate vasoconstriction; may not have a beneficial effect in blood pressure; may increase risk of tachyarrhythmias
May increase infusion by 1-4 mcg/kg/min at 10-30 min intervals until optimum response obtained
Titrate to desired response
Child Dose
Hemodynamic Conditions
Treatment of hypotension
1-5 mcg/kg/min IV, increased to 5-20 mcg/kg/min; not to exceed 50 mcg/kg/min
Titrate to desired response
Renal Dose
Administration
Contra Indications
Pheochromocytoma, uncorrected tachyarrhythmias, ventricular fibrillation. Hypersensitivity.
Precautions
Shock secondary to MI, history of peripheral vascular disease. Correct hypovolaemia before infusion. History of occlusive vascular disease e.g, atherosclerosis, Raynaud's disease, Buerger's disease, diabetic endarteritis; disproportionate increase in diastolic pressure. Pregnancy.
Lactation: Unknown whether drug is excreted into breast milk; use caution
Pregnancy-Lactation
Interactions
Cyclopropane and halogenated hydrocarbon anaesthetics may sensitise myocardium to dopamine and precipitate ventricular arrhythmias. MAO inhibitors prolong and increase dopamine effects. Ergots potentiate vasoconstriction action of dopamine. Alpha-blockers unmask dopamine's beta action.
Adverse Effects
Side effects of Dopamine Hydrochloride :
Cardiovascular: Ventricular arrhythmia, atrial fibrillation (at very high doses), ectopic beats, tachycardia, anginal pain, palpitation, cardiac conduction abnormalities, widened QRS complex, bradycardia, hypotension, hypertension, vasoconstriction
Respiratory: Dyspnea
Gastrointestinal: Nausea, vomiting
Metabolic/nutritional: Azotemia
Central nervous system: Headache, anxiety
Endocrine: Piloerection
Ocular: Increased intraocular pressure; dilated pupils
Gangrene of extremities has occurred when high doses were administered for prolonged periods or in patients with occlusive vascular disease receiving low doses of dopamine hydrochloride
Mechanism of Action
Dopamine stimulates dopaminergic receptors at lower doses producing renal and mesenteric vasodilation while at higher doses stimulate both dopaminergic and ?-adrenergic receptors producing cardiac stimulation and renal vasodilation. It increases heart rate and force of contraction. At low infusion rates vasodilatation occurs in the renal, mesenteric, coronary and cerebral beds. At higher rates vasoconstriction in skeletal muscles and a rise in BP.
Note
Dopatec 40mg/5ml Injection manufactured by National Healthcare Pvt. Ltd.. Its generic name is Dopamine Hydrochloride. Dopatec is availble in Nepal.
Farmaco Nepal drug index information on Dopatec Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.